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《Chinese Journal of Experimental Traditional Medical Formulae》 2014-22
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Lycium chinense Water Extract Attenuates Acute Lung Injury Induced by Lipopolysaccharide in Mice

ZHANG Tian-zhu;ZHANG Jing-long;HAO Bin-bin;XU Jiang;Changchun University of Chinese Medicine;  
Objective: To determine the protective effect of Lycium chinense water extract( LCM) on acute lung injury( ALI) induced by lipopolysaccharide( LPS). Method: The BABL / c mice were randomly allocated into control group,LPS model group,dexamethasone( 2 mg·kg- 1) group,LCM( 10 g·kg- 1),and LCM( 20 g·kg- 1) group by intraperitoneal injection. The bronchoalveolar lavage fluid( BALF) samples were analyzed for the concentration of numbers of neutrophilic, superoxide dismutase( SOD), malondi aldehyde( MDA),interleukin-6( IL-6) and tumor necrosis factor alpha( TNF-α),and the lung samples were taken for histologic evaluation and for determination of wet-to-dry( W / D) lung weight,the protein levels of SOD and MDA were detected by Western blot analysis. Result: Pretreatment with LCM prior to the administration of intratracheal LPS significantly induced a decrease in lung wet weight / dry weight ratio,in total leukocyte number and neutrophil percent in the BALF,and in MDA activity of lung in dose-dependent manners,and in IL-6,the TNF-α in the BALF and MDA protein in lung and increased SOD protein in lung( P 0. 01),compared with model the group.At the same time,compared with the blank group,pretreatment with LCM also significantly improved the SOD activity( P 0. 05) and decreased the MDA activity in lung( P 0. 05). Conclusion: These results showed that anti-inflammatory effects of LCM against the LPS-induced ALI.
【Fund】: 国家自然科学基金项目(81273883);; 吉林省中医药科技项目(2012-083)
【CateGory Index】: R285.5
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