Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Experimental Traditional Medical Formulae》 2015-04
Add to Favorite Get Latest Update

In situ Intestinal Absorption Kinetics of Bajijiasu in Rats

DENG Shao-dong;LIN Jing-ran;LIN Li;XIAO Feng-xia;ZHANG Peng;Guangdong Medical College;College of Chinese Materia Medica,Guangzhou University of Traditional Chinese Medicine;  
Objective: To study the in situ intestinal absorption kinetics of bajijiasu in rats. Method:The absorption of bajijiasu in the small intestine( duodenum, jejunum and ileum) and colon of rats was investigated using an in situ single-pass perfusion method. The drug concentration was measured by HPLC-ELSD.The effects on intestinal absorption of different drug concentration( 43. 92,87. 84,175. 68 mg·L- 1),different p H in perfusate( 5. 4,6. 8,7. 4) and P-glycoprotein( P-gp) inhibitor( 0,0. 2,0. 5 mmol·L- 1) were conducted.Result: Bajijiasu could be absorbed in the whole intestine,and its absorption rate was influenced by the p H of the perfusion solution and intestinal segments. The absorption rate in duodenum,jejunum,ileum and colon was 2. 752-2. 861,1. 435-1. 574,1. 353-1. 403,1. 144-1. 301 h- 1,respecvticvely,the rate declined in turn. Pappin the group containing the P-gp inhibitor increased markedly. Conclusion: The absorption of bajijiasu shows passive diffusion in the general intestinal segments with the first-order kinetic process.
【Fund】: 国家自然科学基金项目(81403085);; 东莞市医疗卫生科技计划一般项目(2014105101295);; 广东医学院科研基金博士学位人员科研启动项目(B2013007)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 9 Hits
1 ZHANG Yu-ling 1,2,CHEN Jian-long 2,WANG Lv-hu 3,SUN Li-ling 2,ZHANG Shi-hang 3,LI Chao-ying 2*,CUI Han-ming 1*(1.Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;2.Changchun University of Chinese Medicine,Changchun 130117,China;3.Guangzhou Zhongyi Pharmaceutical Company Limited,Guangzhou 510140,China);Investigation of Apparent Oil /Water Partition Coefficients of Berberine and Its Absorption Characteristics in in situ Intestinal Perfusion Model[J];中国实验方剂学杂志;2013-16
2 LI Ji,LI Ling-jun,LOU Hua-wei(Shandong University of Traditional Chinese Medicine,Ji'nan 250355,China);In vivo Intestinal Absorption Kinetics Study of Rhynchophylline and Isorhynchophylline of Tiangou Jiangya Capsules[J];中国实验方剂学杂志;2013-06
3 GONG Mengjuan1,YE Wenhua1,XIE Yuanyuan2,WANG Shumei1,LIANG Shengwang1,ZOU Zhongjie1*(1.Chinese Medicine College,Guangdong Pharmaceutical University,Guangzhou 510006,China; 2.Department of Chemistry,Tsinghua University,Beijing 100084,China);Metabonomic study of intervention effects of Morinda officinalis on ` Kidney-yang deficiency syndrome'[J];中国中药杂志;2012-11
4 WANG Jinrong,WANG Ping,YANG Yongmao,MENG Xianli,ZHANG Yan(Chengdu University of Traditional Chinese Medicine,Chengdu 611730,China);Intestinal absorption of aloe-emodin using single-passintestinal perfusion method in rat[J];中国中药杂志;2011-17
5 CH EN Yonggang 1,LIN Li 2,WU Jinhu 1,CHEN Diling 2,ZHUANG Manxian 2 (1.The Third Hospital of Wuhan,Wuhan 430060 Hubei,China;2.School of Chinese Materia Medica,Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China);Stability of Bajijiasu in Simulated Conditions of Human Stomach and Intestines[J];中药新药与临床药理;2011-04
6 XIAO Fengxia1,DENG Shaodong1,LIN Li1,CHENG Yonggang2,DENG Chaoming1(1.School of Chinese Materia Medical,Guangzhou University of TCM,Guangzhou 510006,China;2.The third hospital of Wuhan,Wuhan 430060,China);Study on Absorption Mechanism of DFM by Using Everted Gut Sac Method[J];中药新药与临床药理;2010-06
7 NIE Shu-fang,PAN Wei-san,YANG Xing-gang,LIU Hong-fei,LIU Zhi-dong(Department of Pharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China);Evaluation of gravimetry in the rat single-pass intestinal perfusion technique[J];中国新药杂志;2005-10
8 LIANG Hong-yu,WU Wei,CHEN Hong-gui (Second Traditional Chinese Hospital of Guangdong Province,Guangzhou 510095,China );The preliminary study of bajisu impr oving language function in treating vascular dementia[J];现代康复;2001-21
9 CHEN Jiewen, WANG Yong, TAN Baoxuan, CHEN Chaofeng (Dept. of Physiology, Guangzhou University of TCM, Guangzhou 510405,China);Neuroactivities Basis of BA-JI-SU in Invigorating Kidney to Improve Mental Power[J];广州中医药大学学报;1999-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Deng Long;Wang Yao;Chen Meiling;Xiong Ying;Luo Jiaqi;Tan Shufeng;Wu Wei;Zhou Wen;Jiang Dejian;Wang Xiaoqing;Hunan Center for Safety Evaluation and Research of Drugs,Hunan Key Laboratory for Pharmacodynamics and Safety Evaluation of New Drugs;Medical Research Center(Changsha),Zhuhai Sailong Pharmaceutical Company Limited;;Study on the absorption of monosialotetrahexosylganglioside sodium in rats with in situ cycle intestinal perfusion methods[J];中国医师杂志;2017-04
2 ZHU Liang;YIN Li'na;LIANG Zehua;ZHANG Yawen;HUANG Xiaying;Wu Binli;WANG Shenghao;Department of Pharmacy,Zhejiang Chinese Medicine University;Zhejiang Academy of Medical Sciences;;Study on Intestinal Absorption Parts of Huperize A by in situ Low- speed Single Pass Perfusion Model[J];中华中医药学刊;2015-11
3 ZHAI Xiao-xiao;XU Wen;ZHANG Peng-jun;SHEN Ying-na;WANG Shu-jie;ZHANG Yu-jing;ZHANG Ying;LI Xiao-tian;College of Pharmaceutical,Zhengzhou University;;The Absorption Mechanism of Tetramethylpyrazine in Rat and the Impact of Angelica sinensis Extraction[J];郑州大学学报(理学版);2015-03
4 XU Xue-lin;YI Hong;ZHAO Jie;XIE Xiao-ke;WANG Zhi-min;ZHANG Qi-wei;LIU Xiao-qian;GAO Hui-min;Shaanxi University of Chinese Medicine;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Tianjin University of Traditional Chinese Medicine;Jiangsu Kanion Pharmaceutical Co. Ltd.;;Intestinal Absorption Investigation of Scutellarin Ethyl Ester by in situ Single Pass Intestinal Perfusion Model[J];中国实验方剂学杂志;2015-11
5 DENG Shao-dong;LIN Li;ZHANG Peng;Guangdong Medical College;College of Chinese Materia Medica,Guangzhou University of Traditional Chinese Medicine;;Extraction optimization of oligosaccharides from Morindae Officinalis Radix by multi-index orthogonal experiment[J];中成药;2015-05
6 LI Xin-yang;XIE Hui;LU Tu-lin;SHI Yue-jiao;ZHANG Xing-de;LIU Ting;Nanjing University of Chinese Medicine;;Study on effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids[J];中国中药杂志;2015-09
7 HUANG Li-hua;WANG Jian;ZHANG Lu;LUO Shi-lan;CHEN Chang;DU Juan;Chengdu University of Traditional Chinese Medicine;;Intestinal Absorption Characteristics and Mechanism of Polygala tenuifolia Hydrolysate in Rats[J];中药材;2015-03
8 HUANG Li-hua;WANG Jian;WU Ming-quan;ZHU Zhang-pei;GAO Tian-hui;LU Xiao-hua;College of Pharmacy,Chengdu University of Traditional Chinese Medicine,The Ministry of Education Key Laboratory for Standardization of Chinese Herbal Medicine;;Active elements from Yuanzhi and Houpo,and their intestinal absorption due to the combined use[J];中成药;2015-04
9 LIU Ke;LIU Li-gen;FU Zhi-jun;Department of Chinese Medicine,China Pharmaceutical University;;Research on the Intestinal Absorption of Tenuifolin in Rats by Single Pass Perfusion in Situ[J];海峡药学;2015-04
10 TANG Jing;LUO Li-na;ZHANG Hai-long;ZHENG Zhi-nan;ZHANG Jie;LI Su;HE Hua;DING Jin-song;;Absorption mechanism of SM-1:a procaspase-3-activated anti-tumor agent[J];长沙医学院学报;2015-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 SONG Xue-yun*(The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha,410007,China);Hypotensive Effect of the Alcohol Extract from Gouteng Prescription on Spontaneous Hypertensive Rats[J];中国实验方剂学杂志;2012-11
2 ZHANG Wei,LI Ling-jun,WANG Ying-lan(Shandong University of Traditional Chinese Medicine,Ji'nan 250355,China);Absorption Kinetics of Gastrodin and Paeonol of Tiangou Jangya Capsules in Rats' Intestinal[J];中国实验方剂学杂志;2012-04
3 ZOU Li-juan1,CHEN Ying2,YANG Qing2,LI Yu-jie2,WANG Yi-wei2, WENG Xiao-gang2,DONG Yu3,MEN Wei1,ZHU Xiao-xin1,2(1.Capital Medical University School of Traditional Chinese Medicine,Beijing 100069,China; 2.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 3.Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China);Effect of Compatibility on Intestinal Absorption of Alkaloids in Fructus Evodiae and Rhizoma Coptidis in Rats[J];中国实验方剂学杂志;2012-08
4 HUANG Hou-cai,ZHONG Rong-ling,CAO Peng,SONG Jie,YANG De-gong,XIA Zhi(Jiangsu Provincial Academy of Traditional Chinese Medicine,Nanjing 210028,China);Effects of Gouteng San on the Proliferation and Apoptosis of NIH-3T3 Cell Aging Model[J];中国实验方剂学杂志;2012-03
5 CHEN Diling,CHEN Zhenxing,LIN Li,CHEN Kang,ZHANG Peng,LIANG Xing,LIANG Zheyu,ZHANG Yu,WU Junsheng(School of Chinese Materia Medica,Guangzhou University of Chinese Medicine,Guangzhou 510006,China);In-vivo Intestinal Absorption Mechanism Study for Polysaccharides of Morindae ficinalis[J];中药新药与临床药理;2012-01
6 WANG Juan1,SHAN Jin-jun2*,DI Liu-qing1,WANG Shou-chuan2,CAI Bao-chang1(1.School of Pharmacy,Nanjing University of Chinese Medicine;Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets,Nanjing 210046,China;2.The First Medical College,Nanjing University of Chinese Medicine,Nanjing 210046,China);Simultaneous Determination of Platycodin D and Phenolsulfonphthalein in Rat Bowel Perfusion Fluid by UPLC[J];南京中医药大学学报;2012-01
7 TAN Chao-yuan1,WANG Hai-bo1,2,WANG Dong1(1.Liaoning University of Traditional Chinese Medicine,Dalian 116600,China; 2.Shenyang Pharmaceutical University,Shenyang 110016,China);Study on Uncariae Ramulus Cum Uncis by HPLC-Fingerprints[J];中国实验方剂学杂志;2012-01
8 WANG Hong,SHI Lingyun,YIN Huafeng,ZHOU Qixin*(Department of Pharmacology,Chongqing Medical University,Chongqing 400016,China);Study on effect of berberine on modulating lipid and CPTⅠA gene expression[J];中国中药杂志;2011-19
9 Qian Zhao1, Rui Jin1, Bing Zhang1, Sen-mao Liu2, Min Li1, Xin Liu1, Lian-zhen Li1, Qian Zhang1 1. School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 100102, China2. School of Mathematical Sciences, Peking University, Beijing 100871, China;Ridit analysis of experimental data from animal models of yang deficiency induced by different doses of hydrocortisone[J];中西医结合学报;2011-09
10 SU Hong1,HUANG Chuan-sheng1,CHEN Wen1,WANG Xin-chun2,1(1.Pharmacy of college,Shihezi University,Shihezi 832002,China;2.the first affiliated hospital of medical college,Shihezi University,Shihezi 832008,China);Intestinal Absorption of Shikonin in Rats by in Situ Single Pass Perfusion Method[J];中国实验方剂学杂志;2011-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved