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《Chinese Journal of Experimental Traditional Medical Formulae》 2015-04
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In situ Intestinal Absorption Kinetics of Bajijiasu in Rats

DENG Shao-dong;LIN Jing-ran;LIN Li;XIAO Feng-xia;ZHANG Peng;Guangdong Medical College;College of Chinese Materia Medica,Guangzhou University of Traditional Chinese Medicine;  
Objective: To study the in situ intestinal absorption kinetics of bajijiasu in rats. Method:The absorption of bajijiasu in the small intestine( duodenum, jejunum and ileum) and colon of rats was investigated using an in situ single-pass perfusion method. The drug concentration was measured by HPLC-ELSD.The effects on intestinal absorption of different drug concentration( 43. 92,87. 84,175. 68 mg·L- 1),different p H in perfusate( 5. 4,6. 8,7. 4) and P-glycoprotein( P-gp) inhibitor( 0,0. 2,0. 5 mmol·L- 1) were conducted.Result: Bajijiasu could be absorbed in the whole intestine,and its absorption rate was influenced by the p H of the perfusion solution and intestinal segments. The absorption rate in duodenum,jejunum,ileum and colon was 2. 752-2. 861,1. 435-1. 574,1. 353-1. 403,1. 144-1. 301 h- 1,respecvticvely,the rate declined in turn. Pappin the group containing the P-gp inhibitor increased markedly. Conclusion: The absorption of bajijiasu shows passive diffusion in the general intestinal segments with the first-order kinetic process.
【Fund】: 国家自然科学基金项目(81403085);; 东莞市医疗卫生科技计划一般项目(2014105101295);; 广东医学院科研基金博士学位人员科研启动项目(B2013007)
【CateGory Index】: R285.5
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