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《Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)》 2017-06
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Clinical characteristics and drug resistance of 48 cases with anaerobic bloodstream infections

Wang Yan;Zhang Huiying;Wu Jun;Liu Ying;Liang Qian;The Department of Clinical Laboratory, Beijing Jishuitan Hospital;  
Objective To investigate the clinical characterisitics and the resistance of anaerobic bloodstream infections and to improve the diagnosis and treatment in anaerobic bacteremia. Methods Total of 48 cases with anaerobic bloodstream infections in our hospital were collected from January 2012 to November 2015. The clinical characterisitics, pathogens distribution and drug resistance were analyzed, respectively. Results The most pathogenesis of anaerobic bloodstream infections were gastrointestinal tract diseases and surgical site infections. Total of 53 strains anaerobic bacteria were isolated, and the detection rates of Gram-positive and Gram-negative anaerobic bacteria were 47.17% and 52.83%, which included Peptostreptococcus spp.(20.75%), Bacteroides fragilis(15.09%) and other Bacteroides spp.(22.64%). The positive alarming time within 48 h of Gram-negative anaerobic bacteria was significantly shorter than that of Gram-positive anaerobic bacteria. Among the 53 strains anaerobic bacteria, 100.00% were susceptible to pipperacillin-tazobactam, imipenem and vancomycin. Only 7 isolates of Bacteroides spp. were susceptible to penicillin(35.00%), 11 isolates were susceptible to clindamycin(65.00%). Eight isolates of Gram-positive bacilli(66.67%) and 11 isolates of Gram-positive cocci(86.67%) were susceptible to metronidazoleand. Conclusions The anaerobic bloodstream infections were majored in Gram-negative bacilli. Blood culture played a significant role in anaerobic blood infections. It was important to increase the detection rates of anaerobic bacteria and provide the antimicrobial susceptibility testing in order to reduce the incidence and mortality of anaerobic bloodstream infections.
【Fund】: 北京积水潭医院“学科新星”计划专项经费(No.XKXX201613)
【CateGory Index】: R446.5;R515
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