Effect of ligustrazine hydrochloride on the concentration of TXB2 and 6-Keto-PGF1a of the plasma and ventricular cerebrospinal fluid and intracranial pressure in severe brain injured patients.
Chen Jianliang. et al. Department of Neurosurgery, Shen zhen Peoples Hospital. Shenzhen. 518001
Twenty-eighht cases of brain injured patients were divided into two groups: treated with or with- out ligustrazine hydrochloride respectively. The concentration of TXBi and 6KP in plasma and V CSF were analysed with RIA before and 3 hours after the treatment, and ICP were also recorded at the same time. The result showed: before the treatment, the concentration of TXB2 and 6KP in plasma and VCSF in both groups were significantly higher than that of the controlled group, ligustrazine hydrochloride could reduce the concentration of TXB2 in plasma and VCSF and had no significant influence on ICP. These results suggest that ligustrazine hydrochloride can inhibit the activation of humai platelet following severe brain injury , improve t'ie balance, of TXA2 - PGI2 within the circulatory blood. It also implies that ligustrazine hydrochloride might be used as one of the agents to treat brain injury.
【CateGory Index】： R269