The effect of PNS on the alterations of NO content and NOS activity in brain tissues following MCAO in rats.
Xu Changqing, Xia Zuoli, Shi Yiju, et al. Department of Gerontology, Affiliated Hospital, Taishan Medical College, Shandong Province (271000).
Objective To explore the mechanism of nitric oxide (NO) in ischemic neuronal death and observe whether the protection of ischemic neuronal tissue by panax notoginseng saponins (PNS) was by influencing on NO production or not. Methods The model of right middle cerebral artery oclusion (MCAO) focal cerebral ischemia in rats was established by inserting thread method and the changes of NO concentrations and nitric oxide synthase (NOS) activity in brain tissues were measured and effect of PNS on them was observed. Results The content of NO and activity of NOS significantly increased at 30 min after MCAO. PNS cacld inhibit their increases. There was a significant positive correlation between NO content and NOS activity. Conclusions NO may play an important role in ischemic neuronal damage and PNS can protect against cerebral ischemic neuronal death by decreasing the production of NO.
【CateGory Index】： R743