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《Chinese Journal of Nervous and Mental Diseases》 2012-11
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The study on the effects of antidepressants treatment on the mRNA expression of B-cell lymphoma Leukemia-2 in peripheral leucodyte from patients with treatment-resistant depression

HONG Wu,HU Yingyan,LI Zezhi,YUAN Chengmei,YI Zhenghui,CHEN Jun,WU Zhiguo,HUANG Jia,CAO Lan,YU Shunying,LIU Xiaohua,PENG Daihui,JIANG Kaida,FANG Yiru. Shanghai Mental Health Center,Shanghai Jiaotong University,600 South Wanping Road,Shanghai 200030,China  
Objective To investigate the effects of antidepressants treatment on mRNA expression levels of B-cell lymphoma Leukemia-2 gene(Bcl-2) in peripheral blood mononuclear cells(PBMCs) from patients with treatment-resistant depression(TRD),and whether can affect the levels of Bcl-2 mRNA expression.Methods Twentythree patients with TRD,26 patients with treatment-effective depression(NTRD) and 51 healthy controls were enrolled in the present study.Patients received antidepressants for 8 weeks and HAMD was used to examine the effects of antidepressants.The mRNA expression levels of Bcl-2 in PBMCs from 49 patients with major depressive disorder(MDD) were estimated using relative TaqMan real time quantitative reverse transcription polymerase chain reaction(RT-PCR).Results The levels of Bcl-2 mRNA expression were significantly lower in PBMCs of MDD patients than those of healthy controls [(1.845 ± 1.234) vs.(3.422 ± 2.204)](P 0.01);The mRNA expression levels of Bcl-2 were the lowest in patients with TRD among patents with treatment-effective depression and healthy control [(1.361 ± 0.731) vs.(2.273 ± 1.431) vs.(3.422 ± 2.204)](F = 11.468,P 0.01).After 8 week treatment,the average HAMD decrease rates of TRD were 62.23% in TRD patients and 82.97% in NTRD patients,respectively.The expression levels of Bcl-2 mRNA were significantly increased in TRD patients(1.797 ± 1.035)(P 0.05) but not in NTRD patients(2.623 ± 1.785) after antidepressant treatment.Conclusion This study demonstrates that the decrease in mRNA expression levels of Bcl-2 may be involved in the pathogenesis of major depressive disorder,especially treatment-resistant depression.Acute antidepressant treatment can increase the mRNA expression of Bcl-2 only in NTRD patients.
【Fund】: 国家高科技研究发展计划(编号:2006AA02Z430);; “十五”国家科技攻关计划(编号:2004BA720A21-02);; 国家自然科学基金(81000581);; 上海交通大学医学院“重点学科建设”(编号:沪交医科[2008]-6);; 上海交通大学医学院附属精神卫生中心院级课题(编号:2011-YJ-06)
【CateGory Index】: R749.4
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【References】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Chen;WU Zhi-guo;HONG Wu;WANG Zuo-wei;HU Ying-yan;CAO Lan;CHEN Jun;WANG Yong;PENG Dai-hui;LIU Xiao-hua;YI Zheng-hui;LU Wei-hong;YUAN Cheng-mei;LI Ze-zhi;YU Shun-ying;WU Yan;FANG Yi-ru;Division of Mood Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine;Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences& Yunnan Province,Kunming Institute of Zoology;Hongkou District Mental Health Center;Department of Neurology,Changhai Hospital,Second Military Medical University;Department of Genetics,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine;;Analysis of association between polymorphism of Bcl-2 gene promoter and major depressive disorder and its clinical phenotypes[J];上海交通大学学报(医学版);2014-04
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 HONG Wu,HU Yingyan,LI Zezhi,YUAN Chengmei,YI Zhenghui,CHEN Jun,WU Zhiguo,HUANG Jia,CAO Lan,YU Shunying,LIU Xiaohua,PENG Daihui,JIANG Kaida,FANG Yiru. Shanghai Mental Health Center,Shanghai Jiaotong University,600 South Wanping Road,Shanghai 200030,China;The study on the effects of antidepressants treatment on the mRNA expression of B-cell lymphoma Leukemia-2 in peripheral leucodyte from patients with treatment-resistant depression[J];中国神经精神疾病杂志;2012-11
2 SHI Mei,AN Gang-hui,XU Ye,et al (Mental Health Institute,The First Clinical College,Harbin Medical University,Harbin 150001,China);Association among 5-HT_(1Dβ) receptor gene T371G polymorphism,unipolar depression and symptom phenotype[J];哈尔滨医科大学学报;2007-04
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