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《神经科学通报(英文版)》 2012-02
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Emerging role of Toll-like receptors in the control of pain and itch

Tong Liu1, Yong-Jing Gao1,2, Ru-Rong Ji1 1 Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA 2 Institute of Nautical Medicine, Nantong University, Nantong 226001, China  
Toll-like receptors (TLRs) are germline-encoded pattern-recognition receptors that initiate innate immune responses by recognizing molecular structures shared by a wide range of pathogens, known as pathogen-associated molecular patterns (PAMPs). After tissue injury or cellular stress, TLRs also detect endogenous ligands known as danger-associated molecular patterns (DAMPs). TLRs are expressed in both non-neuronal and neuronal cell types in the central nervous system (CNS) and contribute to both infectious and non-infectious disorders in the CNS. Following tissue insult and nerve injury, TLRs (such as TLR2, TLR3, and TLR4) induce the activation of microglia and astrocytes and the production of the proinflammatory cytokines in the spinal cord, leading to the development and maintenance of inflammatory pain and neuropathic pain. In particular, primary sensory neurons, such as nociceptors, express TLRs (e.g., TLR4 and TLR7) to sense exogenous PAMPs and endogenous DAMPs released after tissue injury and cellular stress. These neuronal TLRs are new players in the processing of pain and itch by increasing the excitability of primary sensory neurons. Given the prevalence of chronic pain and itch and the suffering of affected people, insights into TLR signaling in the nervous system will open a new avenue for the management of clinical pain and itch.
【Fund】: supported by the US National Institutes of Health (R01-DE17794 R01-NS54362 and R01-NS67686)
【CateGory Index】: R363
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【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 Shi Weiwei,He Wenjuan,Ou Shan,Cui Jian,Wen Huizhong,Ruan Huaizhen(Department of Neurobiology,Chongqing Institute of Neuroscience,College of Basic Medical Sciences,Third Military Medical University,Chongqing,400038,China);Dexamethasone suppresses P2Y_1 receptor expression and TNF-α secretion of rat spinal dorsal horn astrocytes in vitro[J];Acta Academiae Medicinae Militaris Tertiae;2010-01
2 SU Rui-bin(Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China);The role of glial activation in the development of pathological pain:implication for new drug discovery[J];Journal of International Pharmaceutical Research;2011-03
3 Cuiping Mao;Longxiao Wei;Qiuli Zhang;Xia Liao;Xiaoli Yang;Ming Zhang;Department of Radiology,the First Affiliated Hospital,School of Medicine,Xi’an Jiaotong University;Department of Pain,the First Affiliated Hospital,School of Medicine,Xi’an Jiaotong University;;Differences in brain structure in patients with distinct sites of chronic pain:A voxel-based morphometric analysis[J];中国神经再生研究(英文版);2013-32
4 LI Hua1,2,CAO Wen-yu1,XU Yang1,LUO Yan-wei1,ZHONG Xiao-ling1,ZHANG Jian-wei1,LI Chang-qi1,LUO Xue-gang1,DAI Ru-ping1,3 1.Department of Anatomy and Neurobiology,Xiangya School of Medicine,Central South University,Changsha 410013;2.Department of Histology and Embryology,Hunan University of Chinese Medicine,Changsha 410208;3.Anesthesia department,Second Hospital of Xiangya School of Medicine,Central South University,Changsha 410011,China;Inflammatory pain induced CBP expression change in rat hippocampus[J];Chinese Journal of Clinical Anatomy;2011-05
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