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《中山医科大学学报》 1990-02
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COMPARATIVE EXPERIMENTAL STUDY OF THE CANINE HEPATIC VASCULAR EXCLUSION UNDER THE NORMOTHERMIC CONDITION AND HYPOTHERMIC PERFUSION

Cao Xiuhu Huang Jiefu Xia Jintang Zhen Yuyang Xie Xiaoyan Xie Yongrong ( Devision of Hepatobiliary Surgery, First Affiliated Hospital)  
In order to find out the biochemical and physiological changes of total hepatic vascular exclusion(THVE), the critical length of the hepatic ischemic period of the normother-mic THVE and the protective effects of the hypothermic perfusion on the hepatic ischemia, the authors randomized 21 dogs into 3 groups: group A, THVE for 45 minutes; group B, THVE for 60 minutes; group C, THVE with hypothermic perfusion for 60 minutes. The postoperative course, survival rates, biochemical, hemodynamic metabolic consequences and pathological changes of the animals were observed. It has been shown that the tolerance of the canine liver for THVE appeares to be 45 minutes, the critical period of 60 minutes of THVE is followed by an increasing number of death (surival rate of group B: 285.%) and severe metabolic upsets and the hypothermic perfuoisn has obvious protective effects on the liver ischemia.
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