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《Journal of Sun Yat-Sen University(Medical Sciences)》 2009-03
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Correlation of Parameters of Dynamic Contrast Enhanced MRI with MVD and Expression of VEGF in Nasopharyngeal Carcinoma

TIAN Li, LIU Li-zhi, FAN Wei-jun* (Medical Imaging and Interventional Radiology Center, The State Key Laboratory of Oncology in Southern China / / Cancer Center, SUN Yat-sen University, Guangzhou 510060, China)  
【Objective】 To investigate the relationship between the parameters of MR dynamic enhancement and microvascular density (MVD) as well as expression of vascular endothelial growth factor (VEGF). 【Methods】 Twenty-eight patients with nasopharyngeal carcinoma underwent dynamical contrast enhanced MR imaging before nasopharyngoscopy. The maximum slope of increase was calculated pixel-by-pixel and displayed by the color-coded parametric maps. The dynamic parameters such as mean maximum slope(MMS), linear maximum slope(LMS), peak value(PV), and percent of signal intensity(SI%) of biopsy regions and "hotspot" were measured. The correlation of dynamic MR parameters with histopathologic results in biopsy regions were analyzed. Wilcoxon signed ranks test of MRI dynamic parameters between "hotspot" and biopsy regions was also performed. 【Results】 A statistically significant positive correlation existed between MMS, LMS, PV, and SI% of biopsy region and MVD (r = 0.834, 0.643, 0.541, 0.397, respectively, P 0.05). A statistically significant positive correlation existed between forementioned indices and expression of VEGF (r = 0.644, 0.635, 0.456, and 0.503, respectively; P 0.05). The "hotspots" were mainly in the central region of tumors and values of MMS, LMS, PV, and SI% in "hotspots" were higher than that of biopsy region (P = 0.000). 【Conclusion】 A positive correlation existed between parameters of MR dynamic enhancement of biopsy region and MVD as well as expression of VEGF. The dynamic enhanced MRI may be a non-invasive method for measuring angiogenesis in nasopharyngeal carcinoma.
【Fund】: 广东省科技计划项目(2008Z1-E181)
【CateGory Index】: R739.63
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