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《ACADEMIC JOURNAL OF SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES》 1998-02
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HLADQA1 ALLELE ANALYSIS IN GUANGDONG HANS WITH SSPPCR

Wu Yaosheng Luo Chaoquan Yang Yinghao Wu Xinyao(Department of Biochemistry,Sun Yatsen University of Medical Sciences, Guangzhou, 510089)  
Objective: Study the frequency distribution of HLA DQA 1 allele in Guangdong Hans to provide a basic data for further anthropologic study and the HLA DQA 1 associated dissease. Methods: HLA DQA 1 alleles were typed by sequence specific primer PCR. The HLA DQA 1 allele can be directly recognized according to the primer pairs used in producing the PCR products. Results:10 DQA 1 alleles were detected among 146 unrelated individuals of Guangdong Hans. The highest frequency among the alleles is DQA1*0301(0.291). The comparison of the observed and expected genotype data by χ2 test was in accord with the HardyWeinberg equilibrium. The genotypes investigated in 10 nuclear families with SSPPCR accorded with dominant Mendelian inheritance. It suggested that the results were reliable. Conclusions: The frequencies of HLA DQA 1 alleles between GD Han population and other 10 groups of Han population showed significant difference using the χ2test (P0.0001),although the highest frequency is DQA 1*0301 in all Han population tested. These results suggested that there are common characterization and individual difference in the hereditary systemes of Han population, and the complexity of genetic heredity in Han populations of south China. Our results provided some significant information for the anthropologic reseach on the ethnics and the with HLA DQA 1 associated disseases.
【Fund】: 美国中华医学基金
【CateGory Index】: R394[.3],
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