Basis and Applied Study of Clinical Diagnosis and Treatment on Viral Hepatitis
Yao Jilu Gao Zhiliang Peng Xiaomao Zhou Yanping Li Gang Chong Yutian Deng Zhide He Youcheng Ke Weiming Lu Weilun (Hepatitis Institute, Depatment of Infectious Diseases, The Third Affiliated Hospital, Sun Yat sen University of Medical Scien
Viral hepatitis is one of the most important infectious diseases in China. It is the most common cause of chronic hepatitis and is closely related to hepatocellular carcinoma. In the past 5 years, we have improved the molecular biology techniques for the diagnosis of this group of diseases, including the establishment of direct amplified heat denatured detection of HCV RNA, detection of pre core region mutant of HBV with RT PCR, dot hybridization and the sequence cloning of HCV and HGV. A series of epidemiologic studies including the investigation of epidemiology of HAV in Guangdong, as well as risk factors study on transmission of HCV, HGV and acute exacerbation in chronic hepatitis B patients was carried out. Preliminary basic study on gene therapy and a series of studies on combination of Chinese traditional medicine with western medicine are also in progress. All these achievements have been rapidly applied to clinical practice and played important roles in the advance of diagnosis and treatment in viral hepatitis.