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《Chinese Journal of Veterinary》 2004-04
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Pathological Study on Experimental Lead Poisoning in Piglets

CHENG Jun, GAO Feng, PAN Yao-qian, WANG Zhe (Faculty of Military Veterinary, Quartermaster University of PLA, Changchun 130062, China)  
Twelve landrace piglets, weighing 8 to 12 kg, were randomly divided into two groups, test group and control group. Test piglets were given a solution containing 60mg lead acetate/kg of body weight every day and control group were fed normally for 14 weeks. Then clinical signs observed in test piglets were weight loss, inappetence, diarrhea, convulsion and muscle tremors. Piglets manifested parvocellular and hypochromic anemia and basophilic, polychromatophilic and acidophilic erythroblasts increased in their blood. Basophilic stippling was also seen. The gross lesions observed were cardiac dilatation and pericardial effusion; livers and kidneys tumefaction, clay-yellow; spleens slight tumefaction, dark red cut sections and obscure structure; lungs expanding, being fragile; gastric and intestinal mucosa flushing, tumefaction, gastric fundus hyperemia and hemorrhage; vessels of pia mater hyperemia. The results of histopathologic examination were as follows: cardiac muscle fiber degeneration and necrosis; liver cells granular degeneration and fatty degeneration, vessels of portal area engorgement;veins of rabecula of spleen dilatation, a large number of red cells infiltrating splenic sinus; epithelium of pulmonary bronchus mucosa and renal tubule degeneration, necrosis; small intestinal and large intestinal mucosa epithelia necrosis and abscission,goblet cells of gland increasing; vessels of brain adventitia expanding and hyperemia, nerve cells edema, cytoplasm lysis. The results of ultrastructure examination were shown below: perinuclear space and nuclear membrane edge obscuring in liver cells, mitochondrions expanding like vacuoles; the nuclei of renal tubule epithelium and mitochondrial matrix deletion partially and vacuolation locally; mitochondrial matrix of nerve cells of cerebrum, cerebellum, brain stem and spinal cord deletion partially, neuroglial cells and nerve fibers appearing lysed patches at different levels. According to the test results in heart, liver, kidney, brain and femur by atomic absorption spectrophotometer, the average quality concentration of lead in blood in piglets was up to 2.64 mg/L. Lead contents in femur were the highest and amounted to 24.6 μg/g, followed by kidney, liver, heart and brain, their average values were 40, 117,130,79,195 and 76 times as big as normal values, respectively.
【Fund】: 国家自然科学基金资助项目 ( 3 0 170 713 )
【CateGory Index】: S856.9
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