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《Chinese Journal of Veterinary Science》 2013-09
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The protective effects and mechanisms of geniposide on bronchial asthma in mice

ZHANG Yu;DENG Yan-hong;Department of Outpatient Clinic of Division of Agriculture,Jilin University;College of Veterinary Medicine,Jilin University;  
In this study we established an Ova-sensitized and-challenged BALB/c allergic asthma model to explore the protective effects of geniposide(Gen)in the non-infectious inflammation reactions of airway and investigate its possible mechanisms.According to the findings,Gen(80 mg/kg)can markedly improve the Ova-challenged hallmarks of asthma including reduction of eosinophil infiltration into pulmonary tissues in BALF as well as the total amounts of inflammatory cells,down-regulate the levels of Th2-associated cytokines(eg.IL-4,IL-5,and IL-13)and eotaxin in BALF,ameliorate the pathophysiological symptoms around bronchia and Ova-driven airway hyperresponsiveness.Collectively,these findings revealed that Gen exerted beneficial effects on Ova-induced asthma probably through the suppression of NF-κB signal transduction,suggesting that Gen can be used to treat asthma and several other diseases and may be applied in researches and developments of some relative drug materials.
【Fund】: 吉林省自然科学基金资助项目(20101579)
【CateGory Index】: S853.7
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