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《Chinese Journal of Veterinary Science》 2015-05
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Nine kinds of Chinese traditional medicine components inhibit proliferation of swine transmissible gastroenteritis virus in vitro

ZHANG Wei-min;HU Rong;GUO Kang-kang;NING Peng-bo;ZHANG Yan-ming;QING Su-zhu;College of Veterinary Medicine,Northwest Agriculture and Forestry University;  
MTT detection and cytopathic effect(CPE)method were used to determine the inhibition of nine kinds of Chinese traditional medicine components included baicalin,andrographolide,emodin,rhein,aloe-emodin,physcion,matrine,oxymatrine and swainsonine on proliferation of TGEV in swine testicular(ST)cells.Real-time fluorescent quantitative PCR(Real-time PCR)was used to determine the proliferation inhibition of baicalin on TGEV in ST cell in further study.The results showed that,nine kinds of Chinese traditional medicine components all have certain proliferation inhibition effect on TGEV in ST cells in vitro,and in the biosynthesis,adsorption protection and direct inactivation effect inhibition rate of baicalin on TGEV in ST cells were 58.23%,88.12% and 58.23% respectively;real-time PCR detection of baicalin showed that three methods of drug administration could reduce the relative mRNA expressional amount of TGEV significantly compared with the virus control group(P0.01).The results showed that nine kinds of Chinese traditional medicine components all had proliferation inhibition on TGEV in ST cells in vitro,and baicalin was the best.
【Fund】: 陕西省科技攻关计划资助项目(2013K01-61-01)
【CateGory Index】: S853.74
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