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《CHINESE JOURNAL OF VETERINARY SCIENCE》 1998-05
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Protective Effect of Anisodamine against Liver Free Radical Injury during Endotoxic Shock in Goats

Tang Zhaoxin (Dep of Anim Med, South China Agri Uni, Guangzhou 230036) Wang Xuanying Gao Hong Chen Wanfang Ma Jifei (Coll of Vet Med, Nanjing Agri Uni)  
Thirty-six hybrid goats were divided randomly into control group (Ⅰ), endotoxic shock group (Ⅱ) with intravenuous injection of E coli endotoxin (1800 endotoxin unit per kilogram body weight, 24 hours apart) and anisodamine pretreated group (Ⅲ). The liver antioxidant functional parameters were examined at 5 h and 12 h postinjection respectively. The liver MDA contents of group Ⅱ were found significantly increased corresponding in time to the reduction of activities of glutathione peroxidase and glutathione reductase, total superoxide dismutase(T SOD), Mn SOD(P0.01, P0.05). Meanwhile, the levels of liver reduced glutathione(GSH), total sulfhydryl group, protein bound(PB SH) and nonprotein bound sulfhydryl group (NP SH) also markedly decreased in group Ⅱ at 5 h and 12 h postinjection. However, the liver MDV contents of group Ⅲ were not increased at 5 h postinjection and were significantly lower than those of group Ⅱ at 12 h postinjection. At 5 h postinjection, the activities of liver GSH Px and GR did not decrease significantly as compared with group Ⅰ. The activities of liver GR were higher than those of group Ⅱ(P0.05). There were no differences of the activities of T SOD, and the levels of liver tissue T SH, NP SH and PB SH between group Ⅰ and Ⅲ. These data revealed the role of free radicals in the pathophysiology of endotoxic shock suggesting that the anisodamine given 10 min prior to endotoxin injection can effectively attenuate the lipid peroxidation.
【Key Words】： endotoxic shock free radical anisodamine liver goat
【Fund】： 国家自然科学基金
【CateGory Index】： S852.33
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