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《Chinese Journal of Laboratory Diagnosis》 2005-02
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Restudy the in vivo spontaneous metastasis of human pulmonary giant cell carcinoma cell sub lines PLA-801C and PLA-801D

WU Wei-xin, WANG Guan-jun, CHEN Xiao, et al.(Hematology and Oncology Department of 1st Hospital of Jilin University, Changchun 130021, China)  
Objective To study the in vivo spontaneous metastasis of human pulmonary giant cell carcinoma cell sub lines PLA-801C and PLA-801D in order to afford animal models and specific data for further study. Methods Established animal spontaneous metastatic modals of subcutaneously transplanted PLA-801C and PLA-801D. The tumorigenicity and metastasis of transplanted tumor cells were judged histologically after sacrifice. Results The tumorigenicity of the two sub lines in nude mice were 100%. The metastasis rates to lymph nodes and lung were 0 and 100% for PLA-801C, 33.33% and 66.67% for PLA-801D transplanted to axillary space, and 16.67%, 41.67% for PLA-801D transplanted to hind legs. These results were different from which made by our predecessors. Conclusion The reason responsible for the change of the tumorigenicity and metastasis are discussed. The PLA-801C and PLA-801D are still be of great significance for the study of tumor metastasis.
【Key Words】: disease models nude mouse lung neoplasm neoplasm metastasis
【CateGory Index】: R734.2
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