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《Chinese Journal of Stereology and Image Analysis》 2002-03
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STUDY ON THE MORPHOMETRY OF THE ALVEOLAR EPITHELIA CELLS OF THE CANINE LUNG DONOR FOR TRANSPLATATION

MENG Hui1, SHEN Hong 2, CHEN Gang1, GAO Ling 3, ZHAO Fei2 (1.Department of Cardiothorac Surgy, Nanfang Hospital, First Military Medical University, Guangzhou 510515,China; 2.Department of Pathology, First Military Medical University, Guangzhou 510515, Chi  
Objective To observe the changes of the structure of the alveolar epithelia cells in canine lungs processed in terms of perfusion with improved Euro-Collins solution(iECS) at 4C and to evaluate the effect of isolated lung preservation thereby. Methods Six healthy dogs were anesthetized to perform pulmonary perfusion with iECS at 4C and the isolated lungs were thereafter stored at 4C to 8C for 0, 30, 60, 120, 180, 240 min respectively. The tissue samples of donor lungs were subsequently tested, and the volume density (Vv), surface density (Sv) as well as the ratio of surface to volume (Rsv) of nucleus in the alveolar epithelia cells and W/D taken for measurement at the given time points, with the unprocessed donor samples per se as the control group. Results The comparison between the control and the experimental group was observed to reveal no significance in Vv, Sv and Rsv and W/D (P0.05),with proportion to the preserved duration. Conclusion The structural characteristics of tissue in the sampled lungs were observed no alteration, and the changes of Vv, Sv and Rsv of nucleus in the alveolar epithelia cells, not obvious. It is thus believed that the iECS could be used effectively to preserve the donor lungs.
【Fund】: 广东省卫生厅高难高新医疗项目(C200059)
【CateGory Index】: R655.3
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