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《Chinese Journal of Pain Medicine》 2011-05
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THE EXPERIMENTAL STUDY OF INTRADISCAL METHYLENE BLUE INJECTION ON THE INFLUENCE OF NO CONCENTRATION IN DEGENERATIVE DISC INDUCED BY ANNULUS FIBROSUS PUNCTURE

KANG Xin-Jian,PENG Bao-Gan(Department of Spinal Surgery,General Hospital of Chinese People's Armed Police Forces,Beijing 100039)  
Objective: To observe the influence of methylene blue(MB) on the NO concentration in degenerative intervertebral disc,and furtherly probe the possible mechanism of MB injection in therapy discogenic low back pain.Methods: We establish animal model of disc degeneration by puncture the intervertebral disc annulus fibrosus,when the discs get degenerated,MB is injected into the degenerative discs,then we observe the changes of concentration of inflammatory mediators by the method of Histology staining and Molecular Biology.What is more,we conduct statistical tests to related records.Conclusion: The abnormal inflammation of the degenerative disc can be forbidden by the injected MB.So we can conclude that which may be one of the possible mechanisms for the therapy of Methylene blue injected to cure Discogenic low back pain.What is more,we also found that MB is safety to the normal disc and may not start the process of disc degeneration during this study.
【CateGory Index】: R245
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