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Effects of total parenteral nutrition on liver in the cirrhotic rats

Luo Shimin, Liang Lijian. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Sun Yan Sen University of Medical Sciences, Guangzhou 510080  
Objective To investigate the effects of adequate total parenteral nutrition(TPN) on cirrhotic liver. Methods Wistar rats were divided into 3 groups: normal group (n=8), cirrhotic TPN group (n=7), and cirrhotic control group (n=6). Survival rate, body weight, live/body weight ratio, nitrogen balance, liver function, hepatic triglycerin (TG) and cholesterol (CHO), the level of portal insulin, C peptide and glucagon were measured, and histologic changes of the liver were observed. Results All animals survived but one rat died of pneumonedema in TPN group, and body weight had not changed significantly. Compared with the control group, serum TBIL ,AST and ALT had not significantly changes ( P 0 05), ,ALB and A/G ratio were decreased significantly ( P 0 05), Liver TG and CHO were increased significantly ( P 0 05), the level of portal glucagon was increased significantly ( P 0 05) but portal insulin, C peptide were not. On the side of the degree of fatty degeneration in the liver, normal group was class 0, while control group and TPN group, respectively, belong to class Ⅰ and class Ⅳ. Observed by electron microscopy showed that hepatocytes have minimal lipid droplets on the control group but a lot of on the TPN group, while mitochondria of both groups was slight swelling. Conclusion Adequate TPN injuries the cirrhotic liver, and TPN also can't increased the level of serum ALB. The further injury must prevent when adminstration TPN on cirrhotic liver and ALB infusion is advised.
【CateGory Index】: R575.2,R-332
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