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《Chinese Journal of Minimally Invasive Neurosurgery》 2009-12
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Mechanism of glutamate-induced lactate changes in rat traumatic brain injury

WAN Dengfeng,HE Jianxiong,GAO Ziyun,et al.Department of Neurosurgery,Jiangxi Provincial People's Hospital,Nanchang 330006,China  
Objective To explore the mechanism of glutamate-induced lactate changes in traumatic brain injury rat.Methods Twenty eight traumatic brain injury rats were randomly divided into control group,kynurenic acid(KYN) perfusion group,ouabain perfusion group and barium(Ba2+) perfusion group,7 rats in each group.Ringer solution,KYN,ouabain and Ba2+ were perfused into the injured cortex of each group respectively.The changes of brain lactate content were observed by microdialysis technique from 45 minutes before to 90 minutes after the rat model establishment.Results The content of lactate was 0.28 ± 0.07 mmol/L before the brain injury in control group.The value was increased after the brain injury and reached peak value(0.75 ± 0.18 mmol/L) in the first 15 min and lasted to 60 min,then decreased to normal level gradually.The increasing amplitude of lactate was attenuated and the time span was shortened after intervention of ouabain and KYN,however,the increasing amplitude and the time span were all increased in Ba2+ perfusion group.Conclusion The mechanism of glutamine-induced lactate changes following brain injury may as follows:the increased glutamate affects the excitatory amino acid-coupled ionic channel,resulting in increasing of K+ outside the cell,activating of Na+-K+ pump,which in turn promote glycolysis and increases lactate level.
【CateGory Index】: R651.15
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