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Study on Effects of Selenium on Lipid Peroxidation and Trace Elements Changes Induced by Fluorine Selenium in Tissue of Rat Testis

Yang Kedi,et al.,(Department of Environmental Health,Tongji Medical University Wuhan 430030)  
In this study,NaF,Na2SeO3 as these two compounents in combination in water were administered to SD male rats seperately for exploration of the effects of selenium on lipid peroxidatopm and trace elements changes in testis tissues caused by fluoride.The results showed that fluoride could induce the increase of lipid peroxides production and trace elements copper.zinc,and iron increament as well as selenium decreament.Supplemented administration of selenium to experimental rats showed the antagonistic action on testicular lipid peroxides production and copper,selenium changes in restis caused by fluoride,moreover,selenium could also recover the zinc and iron level in testis.The key point is that high dosage of fluoride may cause testicular lipid peroxidation,wheareas the selenium possesses the antagonistic action against the lipid peroxidation resulted from fluoride.
【Fund】: 国家教委课题
【CateGory Index】: R111
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