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《Journal of Chinese Microcirculation》 2009-06
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Water Extract of Propolis Ameliorates Mesenteric Microcirculation of Rats Subjected to Small Intestinal Ischemia Reperfusion

YAO Shu-tong,SANG Hui,WANG Jia-fu,SHANG Zhan-ping,GAO Lin-lin,SI Yan-hong. Dept. of Pathophysiology,Taishan Medical College,Taian 271000,China  
Objective To investigate the mechanisms underlying mitigation of ischemia/reperfusion (I-R) injury of water extract of propolis (WEP) by studying the effect of WEP on mesenteric microcirculation of rats subjected to small intestinal I-R. Methods Forty male Wistar rats were randomly divided into sham,I-R and WEP(50,100,200 mg/kg)groups. Model of small intestinal I-R injury was made by clamping super mesenteric artery for 45 min followed by 120 min of reperfusion in rats. Mesenteric microcirculation was detected at the end of reperfusion. The degree of small intestine injury was assessed with Nackel's method and intestinal wet/dry ratio. HE staining was used to observe the pathology of guts of rats. Superoxide dismutase(SOD) activity and malondialehyde(MDA) content in small intestine were detected. Results (1) WEP alleviated significantly the pathologic lesion of small intestine and resulted in a significant decrease in Nackel's score and intestinal wet/dry ratio,compared with those in I-R group(P0.01). (2) The disturbance of the blood flow in microvessel induced by I-R was improved significantly by WEP. In addition,WEP alleviated significantly the decrease of microcirculatory blood velocity (P0.05 vs I-R group) and inhibited the adherence of leukocytes to venule (P0.01 vs I-R group) in a dose-dependent manner. WEP group had more activity of SOD and less content of MDA than I-R group(P0.05). Conclusion WEP protects small intestine from I-R injury by improving intestinal microcirculation
【Fund】: 泰山医学院重点资助项目(2007ZR001)
【CateGory Index】: R285
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