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《CHINESE CRITICAL CARE MEDICINE》 2000-06
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The role of nuclear factor-κB activation in acute lung injury induced by sepsis

GUO Zhenhui,HONG Xin,MAO Baoling,et al. 1Department of Respiratory,Guangzhou General Hospital of Guangzhou Command,Guangzhou 510010  
Objective:To investigate the potential role of nuclear factorκΒ (NFκΒ) activation in acute lung injury (ALI).Methods:Sepsis associated ALI was produced in rats by cecal ligation and puncture.Changes in NFκΒ activity and tumor necrosis factorα (TNFα) levels in pulmonary tissue were determined by eletrophoretic mobility gelshift assay and enzymelinked immunosorbent assay,respectively.Meanwhile,pathologic changes were also examined under optical microscope.Results:Both NFκΒ activity and TNFα level in pulmonary tissue were significantly increased in rats with sepsisinduced ALI.Conclusions:Sepsis could result in NFκΒ activation and NFκΒ associated upregulation of pulmonary TNFα expression in rats with ALI.The inappropriate activation of NFκΒ and excessive expression of TNFα play an important role in the pathogenesis of sepsisinduced ALI.
【Fund】: 国家自然科学基金!重点课题资助项目 (39730 2 10 )
【CateGory Index】: R631
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