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The role of nuclear factor-κB activation in acute lung injury induced by sepsis

GUO Zhenhui,HONG Xin,MAO Baoling,et al. 1Department of Respiratory,Guangzhou General Hospital of Guangzhou Command,Guangzhou 510010  
Objective:To investigate the potential role of nuclear factorκΒ (NFκΒ) activation in acute lung injury (ALI).Methods:Sepsis associated ALI was produced in rats by cecal ligation and puncture.Changes in NFκΒ activity and tumor necrosis factorα (TNFα) levels in pulmonary tissue were determined by eletrophoretic mobility gelshift assay and enzymelinked immunosorbent assay,respectively.Meanwhile,pathologic changes were also examined under optical microscope.Results:Both NFκΒ activity and TNFα level in pulmonary tissue were significantly increased in rats with sepsisinduced ALI.Conclusions:Sepsis could result in NFκΒ activation and NFκΒ associated upregulation of pulmonary TNFα expression in rats with ALI.The inappropriate activation of NFκΒ and excessive expression of TNFα play an important role in the pathogenesis of sepsisinduced ALI.
【Fund】: 国家自然科学基金!重点课题资助项目 (39730 2 10 )
【CateGory Index】: R631
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Chinese Journal Full-text Database 10 Hits
1 WANG Xiao-Bin, JIA Bin, ZHAO Peng-Tao, DONG Ming-Qing, ZHANG Li-Li, LIU Yi, LIN Shu-Xin, LI Zhi-Chao Department of Pathophysioloy, School of Basic Medicine, Fourth Military Medical University, Xi'an 710033, China;Effect of roxithromycin on activity of NF-κB and expression of TNF-α and IL-10 in pulmonary alveolar macrophage[J];Journal of The Fourth Military Medical University;2005-05
2 ;显性吸入性肺炎及其所致急性呼吸窘迫综合征的临床分析[J];International Medicine & Health Guidance News;2006-07
3 WU Hai-qing1,LI Tao-ping2,XU Jian2,HUANG Li3 1.Department of Intensive Care Unit,Longhua Hospital,Shenzhen 518000,China;2.Department of Respiratory Sleep Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;3.Department of Intensive Care Unit,Guangzhou Development District Hospital,Guangzhou 510730,China;Influences of mesenchymal stem cells on NF-κb in endotoxin-induction acute lung injury rat[J];Journal of Clinical Pulmonary Medicine;2012-11
4 JIANG Peng,WANG Jian-chun,ZHAO Yong-mei(Department of Respiratory Disease,The General Urumqi Hospital of Lanzhou Military District,Uygur 830000,China);The antiinflammatory of WY14643 in acute lung injury in rats[J];Medical Journal of West China;2009-01
5 BAI Jie,YU Zhan-biao,YANG Yong-feng,et al. Department of Emergency Medicine,the Affiliated Hospital of Hebei University,Baoding 071000,China;The effects of lipoicacid on interleukin-10 in acute lung injury rat[J];Chinese Journal of Difficult and Complicated Cases;2006-05
6 FANG Chunhong, LIANG Hong, LI Jianjun, XU Hongxin, XIONG Layuan. Depar tment of Dermatology, Renmin Hospital, Wuhan University School of Medicine, Wuha n 430060, China;Study on Nuclear Factor-êB Activation in Skin Lesions of Systemic Lupus Eryt hematosus[J];Chinese Journal of Dermatology;2002-06
7 GUO Zhenhui, ZOU Xiaying, FAN Manxi. Department of Respirat ory Medicine, Guangzhou General Hospital of Guangzhou Commend, Guzngzhou 510010,China;The mechanism of NO inhalation in the treatment of acute lung injury[J];Chinese Journal of Experimental Surgery;2001-06
8 GUO Zhenhui,HONG Xin,MAO Baoling,et al. 1Guangzhou General Hospital of Guangzhou Command,Guangzhou Guangdong 510010;Study on the antiinflammatory mechanism of aspirin[J];CHINESE CRITICAL CARE MEDICINE;2000-10
9 HUANG Yang,LIANG Jihe,JIA Bin,et al.1Department of Emergency,Xijing Hospital Fourth Military Medical University,Xi′an 710032;Regulatory effect of interleukin-10 and nitric oxide on activation of nuclear factor-κB and production of tumor necrosis factor in pulmonary alveolar macrophages induced by lipopolysaccharide[J];Chinese Critical Care Medicine;2001-05
10 HUANG Yang 1,YIN Wen 1,SONG Zujun 1,CAI Chun 1,ZHANG Dongli 2. 1.Department of Emergency,Xijing Hospital,Fourth Military Medical University,Xi′an 710032, Shanxi,China;Effects of nitric oxide on activation of nuclear factor-κB in pulmonary alveolar macrophages in lipopolysac charide-induced acute lung injury[J];Chinese Critical Care Medicine;2002-09
Chinese Journal Full-text Database 10 Hits
1 Lan Hong, Lu You-Yong Beijing Laboratory of Molecular Oncology,Beijing Institute for Cancer Research,School of Oncology, Peking University, Beijing,100034, P.R.China;Effect of Allitridi on Cyclin D1 and p27~(Kip1) Protein Expression in Gastric Carc inoma BGC823 Cells[J];Chinese Journal of Cancer;2003-12
2 LI Jun you SUN Shi rong YAN Ming (Burn institute,304 th hospital of PLA, Beijing 100037);Changes of plasma and tissue myelopetoxidase activity in hypovolemic shock combined with endotoxin challenge[J];Amino Acids & Biotic Resources;2000-04
3 DING Guo-yong1,2,GUO Li1,DU Zhong-jun1,WU Guang-jian1,CHEN Qiang1,LU Ri-feng1,LING Ling1,FAN Hong-xue1(1.Department of Toxicology,School of Public Health,Jilin University,Changchun 130021,China;2.Department of Preventive Medicine,School of Basic Medical Sciences,Taishan Medical University,Taian 271016,China; 3.Department of Nutrition and Food Hygiene,School of Public Health,Jilin University,Changchun 130021,China);Improvement of bone marrow mesenchymal stem cells on kidney function and level of oxidative stress after renal ischemia-reperfusion injury[J];Journal of Jilin University(Medicine Edition);2009-04
4 Lu Changjun Li Ming,e Liu Junying,et al(Department of Respiratory,Affiliated Hospital,Binzhou Medical College,256603);ISOLATION AND CHARACTERIZATION OF INTERSTITIAL MACROPHAGES FROM RAT LUNG[J];JOURNAL OF BINZHOU MEDICAL COLLEGE;1998-01
5 Weihua Xiao~1 1 University of Science and Technology of China,China. 2 Laboratory of Molecular Immunoregulation,NCI-Frederick,Frederick.MD 21702.USA.;Advances in NF-κB Signaling Transduction and Transcription[J];中国免疫学杂志(英文版);2004-06
6 WAN Dong,LUO Yong (Department of Neurology,the first Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);The phenomenon of nuclear factor-κB nuclear translocation and its significance in brain tissue of Wistar rats subjected to focal cerebral ischemia/reperfusion[J];Chongqing Medical Journal;2003-11
7 LANG Zhong bing,WEN Liang (Department of Emergency,the First Affiliated Hospital,the Third Military Medical University,Chongqing 400038,China);Changes of endotoxin,TNF-α,IL-1β,IL-6 and IL-8 in serum of patients with severe trauma[J];Chongqing Medical Journal;2003-12
8 DU Din yuan (Research Institute of Traumatology,Chongqing Emergency Medical Center,Chongqing 400014,China);A review of post-injury multiple organ dysfunction syndrome[J];Journal of Traumatic Surgery;2002-05
9 ;Diagnosis and Treatment of Severe Community-Acquired Pneumonia[J];China Comtemporary Medicine;2000-07
10 TAN Zhao-hua,XU Jun-mei, YANG Zhao-yun,et al. Department of Anesthesiology, The Second Xiangya Hospital, Central South University,changsha 410011,China;The Effects of Ulinastatin on Proinflammatory Cytokine and Oxygen Free Radicals During Acute Lung Injury in Rabbits[J];Journal of Chinese Physician;2004-10
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 CHEN Si-zeng, ZHAO Li-xiang(Department of Gastrointestinal Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian,China);The treatment effects by combinative supplementation of formoterol,indomethacin and roxithromycin on cancer cachexia mice[J];Parenteral & Enteral Nutrition;2010-02
2 ZHANG Wei,JIANG Yao guang,LI Lei (Center of Thoracic Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Alveolar macrophages and acute lung injury[J];Journal of Traumatic Surgery;2003-05
3 ZOU Zhong-dong,ZHANG Zai-zhong,TANG Li-jun,TU Xiao-huang,WANG Lie,WANG Yu Research Institute of General Surgery,Fuzhou General Hospital,PLA Nanjing Military Area Command,Fuzhou 350025,China;Protective effect of Shenfu injection against intestinal barrier dysfunction and second hit in rats with severe acute pancreatitis[J];Academic Journal of Second Military Medical University;2009-08
4 QIAN Pin, ZHANG Fang, QIAN Gui-sheng, CHEN Wei-zhong (Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical Univisity, Chongqing 400037, China);Changes of glucocorticoid receptor expression and activity in rat alveolar macrophages induced by lipopolysaccharide[J];Acta Academiae Medicinae Militaris Tertiae;2004-22
5 LIN Shu-peng, SUN Xue-feng, CHEN Xiang-mei, SHI Suo-zhu, HONG Quan, L? Yang Department of Nephrology, Center of Nephrology and Key Lab of PLA, General Hospital of PLA, Beijing 100853, China;Effect of aging on pulmonary ICAM-1 and MCP-1 expressions in rats with lipopolysaccharideinduced acute lung injury[J];Journal of Southern Medical University;2010-03
6 DU Bin1,QIU Li-ying1,FAN Hong-bin1,YANG Zhi-yong2(1.School of Medicine and Pharmaceuticals,Jiangnan University,Wuxi,Jiangsu 214122,China;2.VIP Ward,Fuyang People's Hospital,Fuyang,Anhui 236004,China);Progresses in the study protective effects of lipoic acid against ischemia-reperfusion injury in major organs[J];Journal of Guangdong Pharmaceutical College;2010-03
7 Wang Xiaoyan,Zhang Liuzhong,Zhou Li,Zhang Li,Zhong Zhulin,Liang Xianquan.Department of Emergency,The First People's Hospital of Guiyang City,Guiyang 550002,China.;Significance and change of blood serum thyroid function and CRP in early time of infectious shock[J];Guizhou Medical Journal;2012-01
8 WANG Weichen1 XIA Yongfu2 HU Yejia1 1 Department of Pathophysiology,Binzhou Medical University,Yantai 264003; 2 Department of Respiratory Medicine,Affiliated Hospital of Binzhou Medical University;Expression and significance of macrophage migration inhibitory factor in ARDS induced in intestinal ischemia-reperfusion[J];Journal of Binzhou Medical University;2012-05
9 ;参附对大鼠失血性休克炎症因子的抑制作用[J];Contemporary Medicine;2013-12
10 WANG Yu;WANG Sheng-qing;Department of Biology and Chemistry,Longnan Teachers College;;Effects of olive leaf extract on lung histological structure and expression of IL-1β and TNF-α in heroin dependence mice[J];Journal of Gansu Agricultural University;2014-06
China Proceedings of conference Full-text Database 1 Hits
1 Gao Dong-na,Zhang Yu First Affiliated Hospital;Dalian Medical University;Dalian 116001;China;;The Development Of Acute lung injury[A];[C];2009
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