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《CHINESE CRITICAL CARE MEDICINE》 2000-06
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Protective effect of mannitol on lung injury after lower limb ischemicreperfusion

CHEN Jianchang,WANG Lenong,SHI Zhenman,et al.Department of Orthopaedics,Ulumqi General Hospital of Lanzhou Command,Ulumqi 830000  
Objective:To observe the protective effect of mannitol on lung injury after lower limb ischemicreperfusion.Methods:110 rats were divided into control group,3hour ischemiareperfusion group and 3hour ischemiareperfusion group treated with mannitol.The histological evaluation of lung tissue was performed at 3hour ischemia,1,2,3 and 24 hours after reperfusion.Results:It was found that pulmonary edema,microvascular congestion,infiltration of large amount of polymorphonuclear neutrophil (PMN) and partial pulmonary collapse were found in experimental group at 3hour ischemia,1,2,3 and 24 hours after reperfusion.However,treatment with mannitol could markedly attenuate pulmonary injury compared with animals without treatment.Conclusions:These data suggest that mannitol can alleviate the pulmonary injury after lower limb ischemicreperfusion.
【Fund】: 兰州军区科研基金!资助项目 ( XH 960 12 )
【CateGory Index】: R363
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