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《Chinese Critical Care Medicine》 2002-10
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Protective effects of methylene blue on heart and lung injury after intestinal ischemia-reperfusion

LIU Yu he 1,WU Xinmin 1,CHEN Jiexiao 2,ZHU Jianghua 1,SHAN Guojin 1 1.Laboratory of Anesthesiology,Peking University,The First Hospital,Beijing 100034,China;2.Department of Anesthesiology,Hanian People's Hospital,Haikou 570000,Hainan,China  
Objective:To investigate the injurious effect on remote organs induced by single organ ischemiareperfusion (IR) and the protective effect of methylene blue(MB) Methods:Intestinal IR was produced by occluding the mesenteric artery in rabbit.Malondialdehyde(MDA) in blood and superoxide dismutase (SOD),catalase (CAT),xanthine oxidase (XO) and superoxide anion (O ÷ 2) in the heart and lung tissue were assayed by boichemical analysis method Results:The response of the heart was different from the lung after intestinal IR for 2 hours The O ÷ 2 content in lung tissue was markly increased ( P 0 05) and O ÷ 2 content in the heart tissue was not changed ( P 0 05) MDA in the blood was increased significantly after intestinal IR In IR group,lung tissue showed a certain extent of damage as compared with heart tissue,and O ÷ 2 increased with the increasing CAT In MB treatment group O ÷ 2 was significantly lower than that in IR group Conclusions:The resistance of the lung to injury is different from the heart after to intestinal IR induced systemic inflammatory response MB can prevent organic damage by reducing the generation of O ÷ 2
【Fund】: 教育部博士学科点专项科研基金资助项目(No.2 0 0 10 0 0 10 71)
【CateGory Index】: R614
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