Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Critical Care Medicine》 2006-11
Add to Favorite Get Latest Update

Clinical study and long-term evaluation of immunomodulation therapy on trauma,severe sepsis and multiple organ dysfunction syndrome patients

HUANG Shun-wei, GUAN Xiang-dong, CHEN Juan, OU YANG Bin. Surgery Intensive Care Unit, the First Affiliated Hospital of Sun-Yat Sen University, Guangzhou 510080 , Guangdong, China  
Objective To study the clinical effect and long-term evaluation of immunomodulation therapy on trauma, severe sepsis and multiple organ dysfunction syndrome (MODS) patients. Methods Prospective, randomized, blind and controlled clinical analysis of 70 patients conforming to the enrolled standard was carried out. They were divided into two groups at random. One was control group (n=34) with regular therapy, and the treatment group (n=36) with ulinastatin plus thymosinα1 on the base of regular therapy for 1 week. The immunological indexes were determined before and after therapy on the 1 st, 3 rd, 7 th, 14 th and 28 th day, including the changes in lymphocyte count, CD14~+ monocytes human leukocyte antigen (locus) DR (HLADR), clinical data and long-term follow-up. Results During hospitalization , 20 patients died in the control group and 13 patients died in the treatment group. There was significant difference between two groups (P0.05) . After 7 up to 28 days of therapy, the counts of lymphocyte and CD14~+ monocytes HLADR were significantly higher than those in control group (all P0.05) . The duration of using mechanical ventilation and pressor agent in the treatment group were shorter than those in the control group (both P0.01 ). The length of stay and the cost in the intensive care unit (ICU) were not significantly increased in the treatment group (both P0.05 ). The long-term survival time in the treatment group was much longer than that in the control group (P0.05). Conclusions Immunomodulation therapy can improve the prognosis of trauma, severe sepsis and MODS patients in a period of 28 days of observation, and lymphocyte counts and CD14~+ monocytes HLADR were increased significantly , showing that immunosuppression can be ameliorated . Immunomodulation therapy can shorten the time of mechanical ventilation and the use of pressor agent, and it does not increase the length of stay and the cost in ICU, and therefore the cost-effectiveness is high. It also can prolong the long-term survival time. The results show that immunomodulation therapy is one of successful therapeutic strategies in the care of critical illness.
【Fund】: 广东省广州市科技攻关计划项目(2003Z3E0301)
【CateGory Index】: R641
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 GUAN Xiang-dong,WU Jian-feng.The First Hospital Affiliated to Guangzhou Zhongshan Univerisity,Guangzhou 510080,China;Severe Sepsis:the implications from diagnostic criteria[J];Medicine & Philosophy(Clinical Decision Making Forum Edition);2006-12
Chinese Journal Full-text Database 2 Hits
1 DAI Jinghong, QIU Haibo, YANG Yi, ZHOU Shaoxia , XU Hongyang, LIU Shaohua , ZHENG Ruiqiang, HUANG Yingzi Department of Critical Care Medicine , Zhong Da Hospital, Institute of Emergency and Critical Care Medicine , Southeast University , Nanjing 210009, China;Severe sepsis in ICU during 1991 to 2001: a clinical epidemiological analysis[J];Chinese Journal of Multiple Organ Diseases in the Elderly;2003-02
2 LIN Hongyuan,GUO Xusheng,YAO Yongming,CHENG Weixin,WENG Zhihua,WEI Wentao,SHENG Zhiyong.Trauma Center,304 th Hospital of PLA,Beijing 100037,China;Clinical trial to verify the value of the CD_(14)~+ monocyte human leukocyte antigen DR as a marker in evaluating immunosuppression in patients with severe sepsis[J];Chinese Critical Care Medicine;2003-03
Chinese Journal Full-text Database 10 Hits
1 HUANG Jian1,YANG Zhi-huan2,CHEN Li-yong3,et al.(1.Intensive Care Unit,Research Insitiute of Field Surgery;2.State Key Laboratory of Trauma,Burn and Combining Injury;3.Department of Anesthesiology,Daping Hospital,Third Military Medical University,Chongqing,400042,China);Activities of vagal nerve reflex pathway induced by lipopolysaccharide in rats[J];Chongqing Medicine;2008-01
2 Gong Zhenhua,Yao Jian,Yang Jun,Ji Jianfeng,Xiang Tie(Department of Burn and Plastic,the Second Affiliated Hospital,Nantong University,Jiangsu 226001,China);Clinical effects of Xuebijing combined with thymosin α_1 in burn patients with sepsis[J];Chongqing Medicine;2011-04
3 YAO Yong-ming,HUANG Li-feng,LIN Hong-yuan (Burns Institute ,First Affiliated Hospital,the Chinese PLA General Hospital, Beijing 100037,China);Improvement in understanding of potential mechanism and immunomodulatory strategy for sepsis[J];Journal of Traumatic Surgery;2007-01
4 LIU Jing-jie,SUI Zhi-fu,ZHU Jing-min,et al.(Department of Burns and Plastic Surgery,General Hospital of Beijing Military Command,Beijing 100038,China);Study of immune opsonization by thymic peptide in severe burned patients[J];Journal of Traumatic Surgery;2009-04
5 GUO Jianying,DENG Qun,GUO Xusheng,LIU Shuangqing,ZHANG Yuhong,HE Zhongjie,LIN Hongyuan Intensive Care Unit,First Affiliated Hospital of General Hospital of PLA,Beijing 100048,China;Ulinastatin combined with thymosin α1 for treatment of severe sepsis: a histopathological observation in rats[J];Journal of Southern Medical University;2012-06
6 HUANG Shun-wei , GUAN Xiang-dong (The First Affiliated Hospital of SunYat-Sen University,Guangzhou 510080, China);Pathogens in nosocomial infection in surgical intensive care unit[J];Chinese Journal of Infection Control;2009-06
7 Yang Guoxing,Yang Hongming,Hu Sen,et al.Neimenggu Medical College,Huhehaote 010059,Neimenggu,China;Influence of thymosin α1 on Ia expression of monocyte in scald rats with delayed fluid resuscitation[J];Infection,Inflammation,Repair;2007-02
8 Yuan Yuanhong,Xiao Zhenghui,Zhang Hui,Lu Xiulan,Luo Haiyan,Xu Zhiyue,Fan Jianghua(Hunan Children's Hospital,Hunan Changsha 410007,China);Changes of T-cell Subsets and Its Clinical Significance in Children with Septic Acute Kidney Injury[J];Journal of Pediatric Pharmacy;2013-07
9 Zheng Lei1,Zhang Chaofeng2 1Department of Pathology,Zhoushan Hospital,Zhoushan(316004),China 2Department of Orthopedic,Zhoushan Hospital,Zhoushan(316004),China;Diagnostic Significance of Determination of HLA-DR+ Antigen on CD14~+ Monocyte for Postoperative Infections in Patients with Lung Resections[J];Journal of Radioimmunology;2013-04
10 WEN Wei-biao,ZHOU Li-xin,LI Yi-nan,et al(The First Hospital of Foshan,Guangdong Foshan 528000,China);Effect of Continuous Blood Purificatio on the Immunomodulation in Severe Sepsis Patients:a Prospective,Randomized,Controlled Clinical Trial[J];Hebei Medicine;2009-04
China Proceedings of conference Full-text Database 1 Hits
1 ;中药912液对急性重症感染患者血流动力学、氧代谢影响的研究[A];[C];2004
Chinese Journal Full-text Database 10 Hits
1 AN Tong-Tong,LIU Xu-Yi,FANG Jian,WU Mei-Na Department of Internal Medicine,School of Oncology,Peking University,Beijing,100036,P.R.China;Primary Assessment of Treatment Effect of Thymosin-induced Neurotoxicity[J];Chinese Journal of Cancer;2004-S1
2 Wang Yunping,Li Boqing,Ding Guihua, et al (Department of Immunology,Binzhou Medical College,Binzhou,256603);THE EFFECT OF RHEUM OFFICINALE BAILLON ON THE PRODUCTION OF IL 1 AND IL 2[J];JOURNAL OF BINZHOU MEDICAL COLLEGE;1998-03
3 PENG Kan-fu,WU Xiong-fei,ZHAO Hong-wen,WANG Jun-xia,WU Yi,WANG Dian-zhen,ZHAO Xiao-lan(Department of Kidney,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Effects of continuous blood purification on cell immune function in MODS patients[J];Acta Academiae Medicinae Militaris Tertiae;2005-18
4 HUANG Deng-peng, YANG Ming, PENG Wei-ping, CHEN Xiao-she, CHEN Zhong-qing Intensive Care Unit, People's Hospital of Lianzhou, Lianzhou 513400, China; Intensive Care Unit, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Prevention and management of lung infections with thymosin α_1 in critical patients with tra- cheotomy[J];Journal of Southern Medical University;2006-01
5 Rong YU1,Yu SUN2,Qing CAI3,Yongheng LI1,Guangying ZHU1 1Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Department of Radiation Oncology;2Department of Pathology,Peking University School of Oncology,Beijing Cancer Hospital and Institute,Beijing 100142,China;3Department of Laboratory Examination,the General Hospital of Air Force PLA,Beijing 100142,China;Effects of Thymosin Alpha-1 on Radiation-induced Pneumonitis[J];Chinese Journal of Lung Cancer;2011-03
6 LUO Cheng-qun, ZHOU Jian-da, CHEN Dao-jin,et al. (Department of Burns and Plastics Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China);Effect of Chinese traditional medicine mixture on inflammatory response in rats with severe burn[J];;2004-01
7 ZHENG Bi-xia,CHENG De-yun,XU Gang,FAN Li-li,YANG Ying,YANG Wei. Department of Respiratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,China;The Prophylactic Effect of Thymosin Alpha 1 on the Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J];Journal of Sichuan University(Medical Science Edition);2008-04
8 Su Lei, Meng Fansu, Tang Youqing, et al. Intensive Care Unit, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China;Monitoring the immune state in patients with posttraumatic sepsis and clinical study on immunoregulatory effect of combined use of ulinastatin and thymosin α_1[J];Medical Journal of Chinese People's Liberation Army;2008-11
9 QIU Haibo,ZHOU Shaoxia,YANG Yi,et al.Department of Critical Care Medicine and Emergency,ZhongDa Hospital,Southeast University,Nanjing 210009;Multiple organ dysfunction syndrome:predictors of mortality and clinical therapeutic strategies.[J];Journal of Emergenoy Medicine;2001-01
10 CAO Shuhua,GAO Hongmei,WANG Yongqiang,et al.Department of ICU,The First Central Hospital of Tianjin,Tianjin,300192;Effects of Shennong 33 on cytokines in rats with multiple organ dysfunction syndrome[J];Journal of Emergency Medicine;2003-02
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 PANG Xiao-lu,WANG Li-li,MENG Fan-ru,WANG Li-hua,WANG Dong,GAO Zhi-ying Department of Blood Purification,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Transforming growth factor beta and T lymphocyte subsets expression in continuous blood purification patients[J];Clinical Focus;2012-12
2 WANG Si-wen,ZHU Jie,ZHOU Xiu-hua,et al.Department of Intensive Care Unit,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China;Comparison of Enternal Nutrition and Total Parenteral Nutrition in the Management of Multiple Organ Dysfunction Syndrome in the Elderly[J];Chinese General Practice;2010-17
3 Shou-fu Wang1,Hui-jian Zhang2,Jian-sheng Li2,Jin-li Qin2,Su-yun Li2,Hai-bin Yu2,Feng Wang3,Ya Li2,Si-hua Liu21. Henan Academy of Traditional Chinese Medicine,Zhengzhou 450004,Henan Province,China2. Institute of Geriatrics,Henan College of Traditional Chinese Medicine,Zhengzhou 450008,Henan Province,China3. Department of Encephalopathy,Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou 450002,Henan Province,China;Effects of Chinese herbal medicine Dusuqing Granule on toll-like receptor 4 signaling in multiple organ injury induced by bacterial pneumonia in aged rats[J];Journal of Chinese Integrative Medicine;2011-01
4 ZHANG Wei-qin,LI Fang-xue,HE Rong-mei,GAN Yu-ping,ZHOU Yu-rong.Infections Department,People's Hospital of Qianxi'nan Prefecture,Xingyi,Guizhou 562400,China;The manifestations and cause analysis of elderly liver cirrhosis patients[J];Modern Preventive Medicine;2012-13
5 WANG Da-cheng. (Department of Neurology,The People’s Hospital of Beihai,The Ninth Affiliated Hospital of Guangxi Medical University,Beihai 536000,China);Clinical characteristics analysis of 102 elderly patients of massive cerebral infarction with multiple organ dysfunction syndrome[J];Journal of Apoplexy and Nervous Diseases;2010-07
6 YU Li,ZHANG Li-xiang,MA Li-hua,et al(1.Department of ICU,No.253 People's Liberation Army Hospital,Hohhot 010051,Inner Mongolia,China;2.Inner Mongolia Military Region IV retired cadres,Hohhot 010010,Inner Mongolia,China;3.Department of Cadre Ward,No.253 People's Liberation Army Hospital,Hohhot 010051,Inner Mongolia,China);Contrastive analysis of elder aged and middle young aged patients with acute cerebrovascular disease combined with multiple organ failure[J];Medical Journal of West China;2013-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Qiu Haibo; Du Bin;Liu Dawei; et al.(Iotenseve care unil of Affiliated Hospital of Railway Medical College, NanJing, 210009);Multiple organ failure: predictors of morbidity and clinical therapeutic strategies[J];JOURNAL OF EMERGENOY MEDICINE;1999-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved