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Change of glucocorticoid receptor in hepatic and cerebral tissues and its role in hemorrhagic rats/

Shi Hanping,Li Jianzhen,Qin Luping,et al  
Change of glucocorticoid receptor(GR) and its role after hemorrhage in adult SD rats were studied.carotid catheterization was performed and bloodletting(040%) done after anesthesia,or different doses of Ru 486 were injected intramuscularly to block tissue GR(0,50% and 80% respectively).Three hr after blood loss (040%) hepatic and cerebral cytoplasmic GR reduced progressively with increasing blood loss.03hr after blood loss(30%),GR reduced progressively with the prolongaiton of blood loss.There was a significantly negative correlation berween tissue GR and the amount and duration of blood loss.After blockade of the GR(0,50% and 80%),bloodletting(10%) was done.It was found that the higher the blocked GR rate the lower the carodid pressure,and the lower the time survival rate.The result showed that hemorrhage could cause significant decrease of GR,and the degree of decreased GR correlated with the seriousness of hemorrhage.GR may be used as an important mark revealing the seriousness of hemorrhage,and predicting the prognosis of hemorrhage.
【CateGory Index】: R-332
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