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《Chinese Journal of Reparative and Reconstructive Surgery》 2005-06
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WEI Ailin, LIU Shiqing, PENG Hao,et al. Department of Orthopaedics, People's Hospital of Wuhan University, Wuhan Hubei, 430060,P. R. China  
Objective To observe the ability to repair bilateral radius bone defect with the composite of (β-tricalcium) phosphate(β-TCP), hyaluronic acid(HA),type I collagen(COL-Ⅰ) and induced marrow stromal cells(MSCs), and to investigate the feasibility of the composite as a bone substitute material. Methods The MSCs of the New Zealand white rabbits were induced into ostoblasts, then combined with β-TCP, HA and COL-Ⅰ. Thirty New Zealand white rabbits were made the bilateral radius bone defects of 2 cm and divided into groups A, B and C. After 8 weeks, β-TCP-HA-COL-Ⅰ-MSCs (group A, n=27 sides), autograft (group B, n=27 sides)and no implant(group C as control, n=6 sides)were implanted into the areas of bilateral radius bone defects, respectively. The structure of the composite was observed by scanning electron microscope. The repairing effect was observed by gross, histomorphology, X-ray examination, and the degradation rate of inorganic substance at 4, 8 and 12 weeks. The ostogenic area and biomechanics of group A were compared with those of group B at 12 weeks. Results The MSCs could stably grow in vitro, relatively rapidly proliferated, and could be induced into the ostoblasts.The composite was porous. The results of gross, histomorphology and X-ray showed that the bone defects were perfectly repaired in group A and group B, but not in group C. The ostogenic area or biomechanics had no statistically significant difference between groups A and B((P)0.05). The weight of inorganic substance in group A were 75% ,57% and 42% at 4,8,12 weeks, respectively. Conclusion MSCs can be used as seed cells in the bone tissue engineering. The composite has porous structure, no reactions of toxicity to the tissue and rapid degradation, and it is an ideal carrier of seed cells.The β-TCP-HA-COL-Ⅰ-MSCs composite has the high ability of repairing bone defect and can serve as an autograft substitute material.
【CateGory Index】: R687
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Chinese Journal Full-text Database 6 Hits
1 XU Zheng-qing,LIN jun,XU Jing-hong(The First Hospital Affiliated to Zhejiang University medical college,Hangzhou 310003,China);Research Progress on the Physicochemical Properties of Improved CPC[J];Journal of Materials Science and Engineering;2009-04
2 Liu Yong1, Pei Guo-xian2, Jiang Shan2, Ren Gao-hong2 1Department of Orthopaedics, 89 Central Hospital of Chinese PLA, Weifang 261021, Shandong Province, China; 2Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China;New porous beta-tricalcium phosphate as a scaffold for bone tissue engineering[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-23
3 ZHANG Yumin, LI Baoxing, LI Ji, et al. Research Center of Tissue Engineering,Southern Medical University, Guangzhou Guangdong, 510515,P.R.China.;FABRICATION OF POROUS POLY LACTIC ACID-BONE MATRIX GELATIN COMPOSITE BIOACTIVE MATERIAL AND ITS OSTEOINDUCTIVE ACTIVITY[J];Chinese Journal of Reparative and Reconstructive Surgery;2007-02
4 LIU Yong, PEI Guoxian, JIANG Shan, et al. Department of Orthopedics and Traumatology, Nanfang Hospital,Southern Medical University, Guangzhou Guangdong, 510515, P.R.China.;NEW POROUS β-TRICALCIUM PHOSPHATE AS SCAFFOLD FOR BONE TISSUE ENGINEERING[J];Chinese Journal of Reparative and Reconstructive Surgery;2007-10
5 Wang Qing-fengCollege of Physical Education,Henan University of Technology,Jiaozuo 454000,Henan Province,China;Tissue engineered bone materials for repair of ankle injury induced by martial arts[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2010-38
6 Yu Meng Department of Orthopaedics,Beijing Shijitan Hospital,Beijing 100038,China;Characteristics of bone tissue engineering scaffold materials for repair of bone defects[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2010-47
Chinese Journal Full-text Database 3 Hits
2 SHAN Yu xing, LIU Yi, XU Xin xiang. Department of Orthopedics Surgery, the First Hospital of Bethune University of Medical Sciences. Changchun Jilin, P. R. China 130021;THE PRIMARY STUDY ON RABBIT BONE MARROW MESENCHYMAL STEM CELLS IN CONSTRUCTING TISSUE-ENGINEERED CARTILAGE[J];Chinese Journal of Reparative and Reconstructive Surgery;2001-01
3 LI Yan lin, YANG Zhi ming, XIE Hui qi, et al. Department of Orthopedic Surgery, the First University Hospital, West China University of Medical Sciences. Chengdu Sichuan, P. R. China 610041.;CELLULAR COMPATIBILITY OF THREE NATURAL XENOGENEIC BONE DERIVED BIOMATERIALS[J];Chinese Journal of Reparative and Reconstructive Surgery;2001-04
Chinese Journal Full-text Database 10 Hits
1 SHAN Yu xing 1, ZHANG Hai yu 2, ZHANG Shao kun 1,LIU Yi 1, XU Xin xiang 1 (1. Department of Orthopaedics, First Hospital, Jilin University, Changchun 130021, China;2. Department of Pediatric Surgery, First Hospital, Jilin University, Changchun 130021, China);Chondrogenic induction of rabbit bone marrow mesenchymal stem cells in vitro[J];Journal of Jilin University of (Medicine Edition);2004-02
2 ;龟甲"滋阴补肾"药效相关研究概况[J];Contemporary Medicine;2009-10
3 CAO Kai~1,HUANG Wei~1,AN Hong~1,JIANG Dian-ming~1,HUANG Lu~2 (~1Department of Orthopaedics,The First Affiliated Hospital,~2Department of Renal Diseases,The Children's Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);Deproteinized bone with VEGF gene transfer for avascular necrosis of the femoral head[J];Acta Academiae Medicinae Militaris Tertiae;2006-03
4 JIN Dan, PEI Guo-xian, WANG Qian (Department of Traumatology and Orthopaedics, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China);Osteogenic potential of the composite of bone marrow stromal cells and BGC material in vivo[J];Journal of First Military Medical University;2000-05
5 FU Wen-yu, LU Yan-meng, PIAO Ying-jie (Central Laboratory, First Military Medical University, Guangzhou 510515, China);Differentiation and telomerase activity of human mesenchymal stem cells[J];Journal of First Military Medical University;2001-11
6 ZHENGLei 1 ,WANGQian 1 ,PEIGuo-xian 2 ,MA Jian-biao 3 ,WANGYi-nong 3 ,WANGXiao-hong 3 Departmentof LaboratoryDiagnosis 1 ,Departmentof TraumatologyandOrthopedics 2 ,NanfangHospital,First MilitaryMedicalUnive;A morphological study of the cellular biocompatability of a new bone-matrix material in vitro[J];Journal of First Military Medical University;2002-01
7 Zeng Donglin,Luo Li.(Department of Oral and Maxilloficial Surgery, Affiliated Hospital of Guilin Medical College,Guilin,541001 China);VITRO CULTIVATION OF HOST ORIGIN OF MARROW STROMAL CELLS FOR TRANSPLANTATION TO REPAIR BONE DEFECT IN RABBIT EXPERIMENT[J];Journal of Guangxi Medical University;2004-01
8 Jia Ying, Chen Bo, et al. Guiyang Medical College, Guiyang 550004;The Comparison of Two Methods for Isolating and Culturing Rat Bone Marrow Mesenchymal Stem Cells in Vitro[J];Guizhou Medical Journal;2005-10
9 SHI Pei-liang 1,GU Xiao-ming 2,CHEN Fu-lin 3,MAO Tian-qiu 3.(1.Department of Stomatology,The 254th Hospital of PLA,Tianjin 050082,China; 2.Department of Stomatology,General Hospital of the Armed Forces,Beijing 100039,China; 3.Department of Dentofacial Surgery,The Fourth Military Medical University,Xi'an 710032,China);Experimental study of tissue-engineered bone with coralline hydroxyapatite as scaffolds[J];Medical Journal of National Defending Forces in North China;2004-06
10 JI Guang-rong, WANG Yan-song, Han Jian-feng, et al. (Department of Orthopeadics ,the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China);Study on the rule of Ad-BMP-2 to promote the osteogenic potential of cultured rabbit mesenchymal stem cells[J];Basic Medical Sciences and Clinics;2004-01
China Proceedings of conference Full-text Database 1 Hits
1 Bensen Tang,Jiang Yong, Peirong Yin Department of orthopaedics surgery, the affiliated hospital of Guiyang Medical College, guiyang, guizhou 550004;Study on bFGF and gelatin sponge co-combined with osteoblasts.[A];[C];2006
Chinese Journal Full-text Database 10 Hits
1 ZHENG Xiao-yan,ZHANG Zhen-ting,FANG Yu. Department of Prosthodontics,Capital Medical University School of Stomatology,Beijing 100050,China;Biological evaluation of domestic carbon fiber-reinforced post materials[J];Beijing Journal of Stomatology;2006-03
2 Yang Zhiming (The First University Hospital ,West China University of Medical Sciences,Chengdu ,P. R. China 610041);Artificial Materials for Bone Repair from Clinical Point of View[J];Materials Review;2000-03
3 XU Jing-hong,CHEN Hong,LI Wan-hong,LIN Jun (Department of stamology,the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China);Preparation of CPC Carried by Eucommia Ulmoides Oliv.Extracts[J];Journal of Materials Science and Engineering;2007-01
4 LIU Feng,ZHAO Jian hua,WANG Yuan liang,et al.(Department of Orthopaedics,Daping Hospital,Third Military Medical Universtiy,Chongqing 400042,China);Reconstruction of bone defect of the lumbar lamina with composite of PLA/HA/DBM:the preliminary outcome[J];Journal of Traumatic Surgery;2003-03
5 Wu Cheng-yu Xu li-qun (Suzhou Institute of Silk Textile Technology, Suzhou 215005, China) Jin Zong-ming (The Analysis and Testing Center of Suzhou University, Suzhou 215000, China);STUDIES ON THE CHANGES OF CRYSTALLINITY AND STRUCTURE OF SILK FIBROIN[J];Acta Sericologica Sinica;1993-02
6 YE Yong~(1) ZHANG Jian-Yun~(1) HUANG Long-Quan~(2*)(~(1)College of Life Sciences,Anhui Agricultural University,Hefei 230036,China;~(2)College of Tea & Food Science,Anhui Agricultural University,Hefei 230036,China);Effect of Glycerin and Glutaraldehyde on the Improvement of Fibroin Membrane[J];Science of Sericulture;2006-02
7 CUI Fu-zai,ZHANG Wei,YU Xing(Biomaterials Laboratory,Department of Material Science & Engineering,Tsinghua University,Beijing 100084,China);Biomimetic self-assembly of nano-fibrils of mineralized collagen[J];Journal of Dalian University;2004-02
8 HUANG Qiu-xia, ZHOU Hou-de, LIAO Er-yuan, et al. Institute of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha 410011, China;Effects of Insulin on the Gene Expression of Insulin Receptor Substrate-2 in MG-63 Cells[J];Journal of Chinese Physician;2005-09
9 LIUJin-biao,CHENJian-ting Departmentof SpinalandOrthopaedicsSurgery,NanfangHospital,FirstMilitaryMedicalUniversity,Guangzhou510515,China;Development of artificial bone made from nacre and polylactic acid and property assessment[J];Journal of First Military Medical University;2002-03
10 LU Yun-tao 1 , YUAN Lin 1 , JIAO Pei-feng 1 , YU Lei 1 , QIU Xiao-zhong 1 , ZHANG Li-sheng 2 , ZHONG Shi-zhen 11 Institute of Clinical Anatomy, First Military Medical University, Guangzhou 510515, China; 2 Department of Anatomy, Shanghai University of Traditional Chinese Medicine, Shanghai 201400, China;In vitro study of formalin-fixed bone tissues for allogeneic bone grafting[J];Journal of First Military Medical University;2004-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 QIAO Guang-yan~(1,2),SU Jian-sheng~1 (1.Department of Prosthetic Dentistry,School of Stomatology,Tongji University,Shanghai 200072; 2.Department of Prosthetic Dentistry,Shanghai Stomatology Disease Center,Shanghai 200001,China);Advances of Composite Scaffold Materials for Bone Tissue Engineering[J];Journal of Oral and Maxillofacial Surgery;2010-05
2 Liu Yong1, Pei Guo-xian2, Jiang Shan2, Liang Shuang-wu2, Zhao Pei-ran21Orthopaedic Institute, the 89 Hospital of Chinese PLA, Weifang 261021, Shandong Province, China; 2Department of Orthopaedic Trauma, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China;Dynamic changes in tissue-engineered bone encapsulated with fascial flap for repairing rabbit large bone defects[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-24
3 Xie Lin1,2,Chen Xiao-feng1,2,Zhou Jia-an1,2,Zhao Na-ru1,2,Zhang Shu-jiang1,21Biomaterials Research Institute,College of Materials Science,2Key Laboratory of Specially Functional Materials,Ministry of Education,South China University of Technology,Guangzhou 510640,Guangdong Province,China;Preparation of a 58S bioglass/chitosan composite porous scaffold[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-03
4 Zhu Xiao-song1, Li Yan-lin1, Guo Hong-tao2, Yang Hao1, Wang Yong-nian11Department of Orthopaedics, First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China; 2Department of Orthopaedics, Kunming General Hospital of Chengdu Military Area Command of Chinese PLA, Kunming 650032, Yunnan Province, China;Repairing the bone defects with biphasic ceramic-like biologic bone[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-08
5 Lü Dan,Sun Ming-lin Department of Orthopeadics,Affiliated Hospital of Medical College of Chinese People's Armed Police Forces,Tianjin 300162,China;Biomechanics of femoral prosthesis following implantation[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-17
6 LI Yanlin1, GUO Hongtao2, HAN Rui1, YANG Hao1, WANG Yongnian1.1Department of Orthopedics, the First A liated Hospital of Kunming Medical College, Kunming Yunnan, 650032, P.R.China;2A liated Orthopedic Hospital of Kunming General Hospital of Chengdu Military Command.;EXPERIMENTAL STUDY ON REPAIRING SEGMENTAL BONE DEFECTS BY BIPHASIC CERAMIC-LIKE BIOLOGIC BONE[J];Chinese Journal of Reparative and Reconstructive Surgery;2009-05
7 MAO En-liang,DAI Hong-lian,LEI Jun,LI Shi-pu (Biomedical Materials and Engineering Research Center,Wuhan University of Technology,Wuhan 430070,China);Preparation of Porous Scaffolds by Using Thermally Induced Phase Separation Combined Porogen-leaching Process[J];Journal of Wuhan University of Technology;2010-12
8 Wang Fu-ke1,Li Yan-lin2,Wang Guo-liang2,Cao Bin2,Li Xiao-lin2,Chen Jian-ming2,Jin Yao-feng2,Wang Yong-nian2 1Department of Head and Neck Surgery,2Department of Orthopaedics,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China;Biphasic ceramic-like bioactive bone compounded by bone morphogenetic protein and basic fibroblast growth factor to repair finger bone defects[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2010-47
9 Huang Yu-chun Department of Physical Education, Henan University of Technology, Zhengzhou 450001, Henan Province, China;Surface modified biomaterials for repairing acute exercise-induced bone damage[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2011-03
10 Zhang Jun-peng Fitness Center,Institute of Physical Education,Henan Polytechnic University,Jiaozuo 454000,Henan Province,China;Exercise-induced cartilage damage repair with tissue engineered cartilage and biological scaffold materials[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2011-08
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Zhu Wenjing;Jin Weifang; Zhang Lili; Zhang Luoxiu; Wang Hongfu(Department of Pharmacoliogy, School of Pharmacy, Instilute of Radiation Medicine,Shanghai Medical University, Shanghai);USE OF MTT ASSAY FOR DETERMINATION OF OSTEOBLASTS VIABILITY AND PROLIFERATION IN VITRO[J];ACTA ATADEMIAE MEDICINAE SHANGHAI;1995-04
2 Fu Rong;The Experimental Study of Culture of Periosteal Osteoblast on Bioactive Materials[J];;1998-02
3 /LiSong chun; Chen Xiaop-ing; Huang Zhanjie et al(The Second mumicipal Hospital of Hangzhou,Hangzhou 310015.);ABSTRACTTHE EVALUATION OF THERAPEUTIC EFFICACY OF MBGC[J];CHINESE JOURNAL OF REPARATIVE AND RECONSTRUCTIVE SURGERY;1995-03
4 Fu Rong, Yang Zhiming. Department of Orthopedic Surgery, 1st University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041;THE EXPERIMENTAL STUDY OF CULTURE OF PERIOSTEAL OSTEOBLAST ON BIOACTIVE MATERIALS/[J];CHINESE JOURNAL OF REPARATIVE AND RECONSTRUCTIVE SURGERY;1996-04
5 Zou Li, Yang Zhiming, Huang Fuguo et al. Department of Orthopedic Surgery, 1st University Hospital, West China University of Medical Sciences, Chengdu P.R.China 610041;IMPLANTATION OF ALLOGENIC OSTEOBLAST COMBINED WITH CALCIUM PHOSPHTA COMPOSITES[J];CHINESE JOURNAL OF REPARATIVE AND RECONSTRUCTIVE SURGERY;1997-05
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