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《Chinese Journal of Reparative and Reconstructive Surgery》 2015-05
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CHEN Yan;XIE Lihong;ZHANG Jie;FU Jianhua;Department of Aesthetic Plastic Surgery,the First Affiliated Hospital of Nanchang University;  
Objective To review the research progress of the roles of inflammation and immune response in the formation of pathological scar.Methods The recent literature concerning the formation mechanism of pathological scar was extensively consulted,inflammation and immune response involved in the formation of pathological scar was reviewed.Results The formation of pathological scar is associated with inflammation and immune response,some inflammatory factors will promote the activation of immune cells,then induce immune cells releasing cytokines and aggravate inflammatory response.However,inflammation response also affects the level of immune response.So they work together to promote the formation of pathological scar by the immuno-inflammatory cells and media.Conclusion The formation of pathological scar is not only related to inflammation response,but also involves in immune response.Moreover,immune response is the new progress in the study of pathological scar mechanism in recent years.Further research of immuno-inflammatory response will provide new ideas and corresponding basis for the prevention of pathological scar.
【Fund】: 国家自然科学基金资助项目(81460295);; 江西省卫生计生委科技计划资助项目(20155201)~~
【CateGory Index】: R622
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