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《China Journal of Modern Medicine》 2001-05
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Chen Jianyong The First People's Hospital of Changde,Hunan 415003 Han Xiuyun Department of Endocrine,Xiangya Hospital,Central-South University,Changsha 410008[  
Objective:To investigate the effect of Losartan on the type Ⅱ diabetic nephropathy(DN).Methods:Fourty cases with type Ⅱ DN were randomly divided into conventional and losartan treatment groups.In Losartan treatment group,Losartan 50mg Qd was given in addition to the conventional treatment regimen for 4 weeks.24hr urine albumin (uAlb) and renal hemodynamic parameter were measured before and after the treatment,respectively.Seventeen healthy people were included as the control group.Results:Following treatment of Losartan,there were significant difference in decrease of 24hr uAlb (P0.05)、filtration fraction (FF) (P0.01),increase of the effective rend plasma flow(ERPF)(P0.01),but no significant change of endogenous creatinine clearance rate(Ccr)(P0.05)。Between the decrease of mean arteriol Bp and 24hr uAlb,there was no significant correlation (P0.05),so was MBP and FF (P0.05).After conventional treatment,24hr uAlb、ERPF、Ccr and FF were no significant change(P0.05).Conclusions:Losartan can decrease 24hr uAlb、FF and increase ERPF while Ccr remains unchanging on DN.This indicates that losartan has certain protective effect on DN.
【CateGory Index】: R587.2
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