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《China Journal of Modern Medicine》 2003-16
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THE EFFECT OF HYPERBARIC OXYGEN ON INFECTIOUS CEREBRAL EDMA IN RABBITS

Zhang Guoyuan,Yang Yujia , Xu Zhenggu,et al. Department of pediatrics,Xiangya Hospital,Changsha 410008  
Objective:The purpose of this article is to study the therapeutic mechanism of hyperbaric oxygen(HBO) on infectious cerebral edema induced by pertussis bacilli(PB) in rabbits through β-endophen(β-EP)contents change in infectious cerebral edma.Methods:Taking madels of infectious cerebra edema in rabbits induced by pertussis bacillito observe the amount clange of β-ED in cortex,nippocampi,blood plasma and cerabrospinal fluid(CSP) by groups of normal Saline(NS ,n=7); Pertussis bacilli(PB,n=7);Hyperbaric oxygen(HBO,n=7).Results:The average water content of the injected hemisphere was significantly higher in group PB (82.65±0.76%) as compared with that of group NS (79.47±0.96%) ( P 0.01). The amount of β-EP in DB (cortex:56.28±11.66pg/mg,Hippocampi:85.97±33.76pg/mg)is significantly higher than relevant areas in NS (Cortex:18.50±2.01pg/mg,Hippocmpi:22.52±6.09pg/mg)respectively( P 0.01).The amount of β-EP blood plasma(106.31±24.96ng/ml) and CSF(2.49±0.66ng/ml)after injected bocilli for 4h increased rapidly compared with the amount of them (Blood plasma:43.80±19.63ng/ml,CSF:1.14±0.39ng/ml) before injection respectirely,which has significant difference. HBO:WC:81.38±0.30,decreased evidently compared with PB.The amount of β-EP in blood palsma and CSF were significantly lower in groups of HBO(63.50±22.48ng/ml, 1.52±0.30ng/ml) than that in group PB (106.33±24.96ng/ml, 2.49±0.66 ng/ml) ( P 0.05).The amount of β-EP in the cerebral cortex and hippcampus is lower in group of HBO (29.54±5.21pg/mg, 38.57±10.90pg/mg) than in group of PB in injected hemisphere,which has significant difference. ( P 0.01).Conclusions:The results suggest β-EP increase signiticantly in brain tissue, blood plasma and CSF on infectious cerebral edema. HBO has effective treatment to infectious cerebral edma.
【CateGory Index】: R459.5
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【Citations】
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1 CHEN Ping;KUANG Hong-yu;WANG Yan;LI Yue;SHAO Ning;Department of Endocrinology,The First Affiliated Hospital of Harbin Medical University;;Advances of Hyperbaric Oxygen Therapy in Diabetic Retinopathy[J];现代生物医学进展;2014-18
2 WANG Ling(Department of Emergency Medicine,The second Hospital of Dazhou City,Sichuan,635000 Chian);Effects of Naloxone in Treating Acute Cerebral Infarction[J];中国伤残医学;2012-12
3 ZHENG Xiao-qiu,WANG Xiang-bing,CHEN Dai-jing,ZHANG Ji-cheng,DU Yi-ping;Hyperbaric oxygen combined with drug treatment and functional exercise for cerebral infarction:Observations on 83 cases[J];实用医院临床杂志;2011-04
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6 XIE Hui,TANG Si-ming,ZHOU Yuan-fang.Department of Neurology,The Third People's Hospital of Guangyuan,Guangyuan,Sichuan 628001,China;Hyperbaric oxygen therapy clinical effects of cerebral infarction[J];四川医学;2008-09
7 SHAO Ying,LAI Xin-sheng,GONG Yu-zhuo,YAN Bing,HE Li-lei,LUO Ren,TANG Chun-zhi(College of Acu-moxibustion and Massage,Guangzhou University of Chinese Medicine,Guangzhou 510405,China);Effects of Electroacupuncture on Plasma and Cerebral Somatostatin and β-EP Contents and Learning-memory Ability in Vascular Dementia Rats[J];针刺研究;2008-02
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