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《China Journal of Modern Medicine》 2006-09
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Expression of NF-КB and HIF-1a induced by Quercetin combination with DDP in lung adenocarcinoma in mice

WANG Li-zhong, HE Jian-bin, LI Jie-ping, ZHANG Shu-jie, ZHANG Ping (Department of Respiration, the First Affiliated Hospital of Nanhua University, Hengyang, Hunan 421001, P.R.China)  
[Objective] To study the interaction nuclear factor-kappaB( NF-КB ) and hypoxia inducible factor 1a (HIF-1a) in lung adenocarcinoma LA795 in mice induced by Quercetin combination with DDP. [Methods] LA795 cells were inoculated into T739 mice to eslablish lung adenocarcinoma model, 32 T739 mice bearing high metastatic LA795 cells were randomized into four groups: A: control group; B: DDP group; C: Quercetin group; D: Quercetin + DDP group. Different treatments were served from 4th day after transplantation and all mice were sacrificed after 24 days. Lung and subcutaneous tumors were processed for histological examination. The metastatic tumor foci on lung in mice, tumor weight and tumor growth inhibition rate were observed, lung metastatic occurring rate and metastatic foci inhibitory rate were counted, subcutaneous tumor NF-КB and HIF-1a were determined by immunohistochemistry method with image analyse system. [Results] In each treatment group, tumor growth was suppressed significantly, intraperitoneal injection of DDP, quercetin and their combination resulted in a significant inhibition on the growth of LA795 cells in vivo (P 0.05), the combination group significant enhancement in anti-tumor efficacy. The metastatic foci on lung surface were obviousy inhibited by Quercetin and Quercetin +DDP compared to the control group. Contrary to DDP, the expression of subcutaneous tumor NF-КB and HIF-1a were obviously inhibited by Quercetin and the combined group. The combined group shows great synergetic effect in decreaseing metastatic foci on lung surface. [Conclusion] Quercetin combination with DDP can inhibit tumor growth and lung metastasis in vivo of lung adenocarcinoma LA795 in mice. The fact that they inhibited tumor growth and lung metastasis of lung adenocarcinoma LA795 may be associated its effect by suppressing the expression of NF-κB and HIF-1a in tumor.
【Fund】: 湖南省卫生厅科研基金资助 编号C2005033
【CateGory Index】: R734.2
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