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《China Journal of Modern Medicine》 2007-02
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Effect of Gypenoside on blood lipid and micralbuminuria in paitients with type 2 diabetes mellitus

HUANG Ping1, CHENG Jing-long1, ZHANG Lei2, LIN Bin2 (1.Department of Geriatrics, the First Municipal People′s Hospital, Guangzhou, Guangdong 510180, P.R.China; 2.Department of Emergency, Liwan Hospital of Guangzhou Medical College, Guangzhou, Guangdong 510170, P.R.China)  
[Objectives] To investigate the effect of Gypenoside on blood lipid and micralbuminuria in patients with type 2 diabetes mellitus. [Methods] 108 patients with type 2 diabetes mellitus were divided into four groups according to the drugs they received Group: 38 patients with type 2 diabetes mellitus received treatment of gypenoside; Group ARB: 36 patients with type 2 diabetes mellitus received treatment of ARB; Group control: 36 patients with type 2 diabetes mellitus. All the patients received treatment of oral drugs. Blood pressure could be controlled at 130/80 mmHg combined with CCB and β-blocker in patients with hypertension, the period of investigation was 24 weeks. [Results] Before and after the treatment, compared with control group, TG D-LDL and AER decreased significantly in patients with treatment of gypenoside (P 0.01). Compared with Group ARB, TG and D-LDL decreased significantly in patients with treatment of (P 0.05). There were similar decrease of AER in the patient with treatment of gypenoside and ARB. [Conclusions] Gypenoside can significantly improve the renal function and decrease blood lipid.
【Fund】: 2005年广州市中医药中西医结合科研课题立项(2005B004)
【CateGory Index】: R259
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