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《China Journal of Modern Medicine》 2007-18
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Relationship between smoking, bone turnover and bone mineral density in healthy Chinese men

YANG Ling-feng, ZHAO Qin, ZHANG Hong, WU Xian-ping, XIE Hui, LIU Li-jun, SHAN Peng-fei, CAO Xing-zhi, LUO Xiang-hang, LIAO Er-yuan (Institue of Endocrinology and Metabolosm, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R.China)  
[Objective] To study the relationships of smoking and bone alkaline phosphatase (BAP), serum osteocalcin (sOC) and cross-linked N-telopeptides of type 1 collegen(sNTX)and bone mineral density in healthy men aged 20~80. [Methods] BAP, sOC, and sNTX were measured using ELISA and BMD at lumbar spine and hip was measured by dual energy x-ray densitometer, and correlation of bone biochemical marker with age and BMD were fitted by ten kinds of regression models. [Result] All subjectes were categorized into two groups according to smoking or not, and there was a lower mean BMD of all sites and a higher sOC and BAP values in those smoking men (all P 0.05). After adjusted age and BMI, the year of smoking was negatively correlated with BMD values at at all sites but supine lateral lumbar spine and positively with the sOC values. Daily smoking amount was negatively correlated with BMD values at anteroposterior (AP) lumbar spine and Ward′s region while positively with the sOC values (all P 0.05). [Conclusion] Smoking raises bone turnover rate and accelerates bone lose. In order to prevent osteoporosis, smoking should be inhibited.
【CateGory Index】: R580
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