Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《China Journal of Modern Medicine》 2008-04
Add to Favorite Get Latest Update

Inhibitory effects of suramin on lung adencarcinoma and expression of bFGF in mice

HE Jian-bing1,XIANG Zhi1,YANG Kai2,ZHANG Ping2 (1.Department of Respiration,the First People′s Hospital of Huaihua,Huaihua,Hunan 418000,P.R.China; 2.Department of Respiration,the First Affliliated Hospital of Nanhua University,Hengyang,Hunan 421001,P.R.China)  
Objective To study the effect of suramin in combination with DDP on the growth,lung metastasis and expression of bFGF of lung adenocarcinoma LA795 in vivo in mice. Method 32 T739 mice bearing high metastatic LA795 cells were randomly divided into four groups: control group,DDP group,suramin group,and DDP + Suramin groupe. Different treatment therapy were served from day 4 after transplantation and all mice were sacrificed after 24 days. lung and subcutaneous tumors were processed for histological examination. The metastatic tumor foci on lung in mice,Lung metastatic occurring rate and metastatic foci inhibitory rate were counted. Subcutaneous tumor microvessel density (MVD),and the expression of basic fibroblast growth factor (bFGF) were detected by immunhistochemical method with image analyse system. Results In every treatment group,tumor growth was suppressed significantly. Intraperitoneal injection of DDP,suramin and their combination resulted in significant inhibition on the growth of LA795 cells in vivo (P 0.05),the combination group showed significant increase in anti-tumor efficacy,with growth inhibition rate of 23.0%,34.4% and 56.3%,respectively. Necrosis and decrease of vessels in the tumor and morphological changes of endothelium were observed under light microscope in suramin group and DDP + Suramin group. Immunohistochemical staining of MVD and bFGF showed that Suramin group and DDP + Suramin group were significant lower than control group (P 0.01). The metastatic foci on lung surface were obviousy inhibited by suramin and suramin+DDP compared to DDP and the control group. Contracted to DDP,the expression of subcutaneous tumor MVD,bFGF and lung metastatic occurring rate were also obviously inhibited by suramin. The combined group showed great synergetic effect in decreaseing metastatic foci on lung surface. Conclusion Suramin can inhibit tumor angiogenesis in lung adencarcinoma and has strong inhibit effectory on both tumor growth and lung metastasis of adenocarcinoma transplanted in T739 mice.
【Fund】: 湖南省卫生厅科研基金资助(编号C2005033)
【CateGory Index】: R734.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 LU Feng (Obstetrics and Gynecology in the First People's Hospital in Pingjiang,Pingjiang 414500,China);Expression of bFGF and CD105 in human cervical carcinoma tissue and it's biological behavior[J];China Modern Medicine;2009-18
【Citations】
Chinese Journal Full-text Database 3 Hits
1 ;长必安协同顺铂在裸鼠体内抗肿瘤生长和转移作用的实验研究[J];Zhejiang Clinical Medical Journal;2001-01
2 XIE Qing-xiang1, XU Zhong-yi2, LIN Xia-Cong1, ZHAO Li1, ZHANG Yang-gen2 (1.Department of Urology, 2.Medical Laborotary, the 175th Hospital of PLA, Zhangzhou, Fujiang 363000, P.R.China);Expressions of serum and urine bFGF in patients with bladder cancer[J];China Journal of Modern Medicine;2005-08
3 HE Jian-Bin1,ZHANG Ping 1*,WANG Xiao-Hua1,OU Li-Wen1,LONG Zhi-Feng2 (1.Department of Respiration,First Affiliated Hospital of Nanhua University,Hengyang 421001,China; 2.Department of Histology and Embryology,Medical College of Nanhua University,Hengyang 421001,China);Inhibitory effects of quercetin in combination with suramin on growth of lung adenocarcinoma in mice[J];Tumor;2006-04
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 ZHANG Ping, HE Jian-Bin, OU Li-Wen, WANG Xiao-HuaDepartment of Respiratory Medicine, The First Affiliated Hospital, Nanhua University, Hengyang, Hunan, 421001,P. R. China;Effects of Suramin in Combination with Cisplatin on Growth and Metastasis of Lung Adenocarcinoma Xenografts in Mice[J];Chinese Journal of Cancer;2006-04
2 HE Jian-Bin1, YI Gao-Zhong1, YANG Kai1, XIANG Zhi1, XIE Mao-Feng1, ZHANG Ping21. Department of Respiratory Diseases, The First People’s Hospital of Huaihua City, Huaihua, Hunan, 418000, P. R. China 2. Department of Respiratory Diseases, The First Affliliated Hospital, Nanhua University, Hengyang, Hunan, 421001, P. R. China;Inhibitory Effects of Suramin on Growth of Transplanted Lung Adencarcinoma in Mice and Its Mechanisms[J];Chinese Journal of Cancer;2008-04
3 Yong Zhao1,2,Bin Ren2,Xiao-Wei Gao2,Yun-Xian Gao2,Xia Li1,Hui Li1,Ji-Hua Guo3 1Graduate School,Medical College,Shihezi University,Shihezi 832003,Xinjiang Uyghur Autonomous Region,China;2Department of Ophthalmology,Center of Ophthalmology of Chinese PLA,3 Department of Pathology,No.474 Hospital of Chinese PLA,Urumuqi 830011,Xinjiang Uyghur Autonomous Region,China;Effect of TNP470 on treatment of oxygen induced retinopathy in rats[J];International Journal of Ophthalmology;2007-04
4 ZHANG Lei,WANG Wenli,WANG Guiqi. Department of Surgery,The First Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050011;Therapeutic effect of TNP-470 on primary breast cancer in rats[J];Hebei Medical Journal;2007-11
5 HE Jian-bin, ZHANG Ping, OU Li-wen, WANG Xiao-hua Department of Respiration, First Affiliated Hospital of Nanhua University, Hengyang 421001, P.R.China;Expressions of HIF-1α and P-Selectin induced by Suramin combination with Quercetin in lung adenocarcinoma in mice[J];Chinese Journal of Cancer Prevention and Treatment;2006-11
6 WANG Xuping1,YAN Lirong1,BI Shengli1,HUANG Wen2,ZHU Wei2 1 The Second Affiliated Hospital,The Medical College of Hebei North College,Xuanhua 075100;2 Department of Gast roenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433;Changes of serum bFGF,ColⅣ and HA in perioperative period patients with ovarian cancer[J];Journal of Practical Oncology;2007-04
7 HE Jian-bin1,ZHANG Yi-qiu1,XIANG Zhi1,TANG Jian-xin1,YI Gao-zhong1,ZHANG Ping2(1.Department of Respiration,First People's Hospital of Huaihua,Huaihua 418000,China;2.Department of Respiration,First Affiliated Hospital of Nanhua University,Hengyang 421001,China);The regulatory effects of quercetin combined with DDP on Bcl-2 and Bax expressions in transplanted lung adenocarcinoma in mice and their significance[J];Tumor;2008-05
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Xu Shenhua; Mou Hanzhou; Qian Lijuan, et al. (Zhejiang CancerResearch Institute, Hangzhou 310022);Establishment and characterization of a model of highly metastatic human ovarian cancer transplanted subcutaneously into nude mice[J];Chinese Journal of Pathology;1996-01
2 ZHANG Guangyu *, ZHAO Min, XU Mingtang, YANG Yonghui,WANG Mengshan,YANG Chunzheng *State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300020, China;Correlation of angiogenesis with expression of vascular endothelial growth factor and its receptors in lung carcinoma[J];Chinese Journal of Tuberculosis and Respiratory Diseases;2002-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved