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《China Journal of Modern Medicine》 2008-04
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Inhibitory effects of suramin on lung adencarcinoma and expression of bFGF in mice

HE Jian-bing1,XIANG Zhi1,YANG Kai2,ZHANG Ping2 (1.Department of Respiration,the First People′s Hospital of Huaihua,Huaihua,Hunan 418000,P.R.China; 2.Department of Respiration,the First Affliliated Hospital of Nanhua University,Hengyang,Hunan 421001,P.R.China)  
Objective To study the effect of suramin in combination with DDP on the growth,lung metastasis and expression of bFGF of lung adenocarcinoma LA795 in vivo in mice. Method 32 T739 mice bearing high metastatic LA795 cells were randomly divided into four groups: control group,DDP group,suramin group,and DDP + Suramin groupe. Different treatment therapy were served from day 4 after transplantation and all mice were sacrificed after 24 days. lung and subcutaneous tumors were processed for histological examination. The metastatic tumor foci on lung in mice,Lung metastatic occurring rate and metastatic foci inhibitory rate were counted. Subcutaneous tumor microvessel density (MVD),and the expression of basic fibroblast growth factor (bFGF) were detected by immunhistochemical method with image analyse system. Results In every treatment group,tumor growth was suppressed significantly. Intraperitoneal injection of DDP,suramin and their combination resulted in significant inhibition on the growth of LA795 cells in vivo (P 0.05),the combination group showed significant increase in anti-tumor efficacy,with growth inhibition rate of 23.0%,34.4% and 56.3%,respectively. Necrosis and decrease of vessels in the tumor and morphological changes of endothelium were observed under light microscope in suramin group and DDP + Suramin group. Immunohistochemical staining of MVD and bFGF showed that Suramin group and DDP + Suramin group were significant lower than control group (P 0.01). The metastatic foci on lung surface were obviousy inhibited by suramin and suramin+DDP compared to DDP and the control group. Contracted to DDP,the expression of subcutaneous tumor MVD,bFGF and lung metastatic occurring rate were also obviously inhibited by suramin. The combined group showed great synergetic effect in decreaseing metastatic foci on lung surface. Conclusion Suramin can inhibit tumor angiogenesis in lung adencarcinoma and has strong inhibit effectory on both tumor growth and lung metastasis of adenocarcinoma transplanted in T739 mice.
【Fund】: 湖南省卫生厅科研基金资助(编号C2005033)
【CateGory Index】: R734.2
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