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《China Journal of Modern Medicine》 2009-13
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Polymorphisms of E-selectin S128R gene and genetic susceptibility of cerbral thrombosis

ZHANG Yunli1, TANG Tiantian1, FANG Boyan2 (1.Department of Laboratory, 2.Department of Neurology, the First Affiliated Hospital of Liaoning Medical College, Jinzhou, Liaoning 121001, P.R.China)  
【Objective】To study the relationship between polymorphisms of E-selectin gene and cerbral thrombosis in Han nationality of Liaoning province. 【Methods】The S128R polymorphism in the exon 4 of E-selectin gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and DNA sequencing among 120 patients with cerbral thrombosis of Han nationality in Liaoning and 102 healthy controls. The effects of E-selectin genotypes on serum lipids, serum glucose variation were analyzed. The serum level of E-selectin was determined by enzyme-linked immunosorbent assay (ELISA). 【Results】There was significant difference in frequencies of allele and genotype in S128R polymorphism between cerbral thrombosis and control groups respectively (χ2=6.39, P 0.05). The relative risk suffered from cerbral thrombosis of SR genotype was 3.05 times of the SS genotype (OR=3.05, 95%CI: 1.29~7.20). Allele frequency in SS and SR is also significant difference (χ2=5.94,P 0.05, OR=2.84, 95%CI: 1.23~6.55). 【Conclusions】E-selectin S128R polymorphism was associated with cerbral thrombosis, and R allele may be a genetic risk factor of cerbral thrombosis among Han nationality, in whom the E-selectin SR genotype carriers maybe increase the risk of cerbral thrombosis by enhancing the E-selectin expression.
【Fund】: 辽宁省自然科学基金(No:20082179)
【CateGory Index】: R743.32
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