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《China Journal of Modern Medicine》 2011-31
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Protective action and its mechanism of polysaccharides on immunological liver injury

ZHONG Ping1,WANG Yun-fu2,LI Ping1(1.Medical Health-care Center,Hubei University of Medicine,Shiyan,Hubei 442000,P.R.China;2.The First Clinical Hospital,Shiyan,Hubei442000,P.R.China)  
【Objective】 To observe the effective of CVP and its mechanism on immunological liver injury.【Methods】 Mice were randomly divided into normal control group,Pathological model,high-level CVP group,medium-level CVP group and low-level group.On the first day of modeling,all the groups but the normal control group were administered 2.5mg BCG.The CVP groups were given(100,200,300) mg/kg CVP once,by body weight per day.On the 12th day,2h after the administration,model group and the CVP groups were injected LPS 7.5 μg/mouse through the tail vein.After 16h,the mice were taken to weigh,separate blood serum from eyes and determinate ALT and AST.Afterwards,mice were killed,and the liver and thymus were immediately removed to weigh,which were used to calculate the liver somatic index,thymus index.liver homogenates were prepared to test SOD,GSH-Px,NOS activity and the MDA,GSH,NO,TNF-α levels.【Results】 Compared with model group,CVP reduced the liver somatic index and serum ALT and AST activity(P 0.05),increased GSH-Px activity and GSH content(P 0.01),decreased NOS activity and MDA,NO,TNF-α contents(P 0.01).【Conclusion】 CVP can reduce the liver injury caused by inflammatory infiltration,increase antioxidant enzyme activity and GSH content,accelerate free radical scavenging,and reduce MDA,NO,TNF-α levels.CVP protects against immunological liver injury.
【CateGory Index】: R285.5
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