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《China Journal of Modern Medicine》 2013-13
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The expression and evaluation of urine NMP22 and Cox-2 protein in superficial bladder carcinoma

LI Bin,LIN Zhe,ZHANG Hai-bin,XIA Tao-lin(Department of Urology,the First Peoples Hospital of Foshan,Foshan, Guangdong 528000,P.R.China)  
【Objective】 To compare the expression of urine NMP22 and Cox-2 protein in superficial bladder carcinoma in pretreatment and posttreatment and study the evaluation in diagnosis and follow-up.【Methods】 Urine NMP22 and Cox-2 protein were collected from 40 cases with superficial bladder transitional cell carcinoma and other 40 controls.All 40 cases received regular bladder perfusion chemotherapy and microscopic examination after transurethral resection of bladder tumor.Urine NMP22 and Cox-2 protein were collected before microscopic examination.The time of positive expression of Urine NMP22 and Cox-2 protein and the time of tumor recurrence found by microscopic examination were compared.【Results】 The sensitivities of urine NMP22 and Cox-2 protein was 62.5%and 80% respectively,the specificity was 85.0%and 95.0% respectively,and the Youden index was 47.5% and 75.0% respectively.The sensitivity and Youden index of urine Cox-2 protein were significantly higher than those of NMP22(P 0.05).The time of positive expression of Urine NMP22 and Cox-2 protein was earlier 4.4 and 5.8 months than tumor recurrence found by microscopic examination in follow-up.【Conclusions】 Urine Cox-2 protein and NMP22 are sensitive and specific markers in the diagnosis of superficial bladder transitional cell carcinoma.
【CateGory Index】: R737.14
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【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Lu Wensheng, Yu Dexin, Zhou Qing et al (Dept of Biochemistry and Laboratory of Molecular Biology, Anhui Medical University, Hefei 230032 );Inactivation of the p16/MTSI gene in bladder cancer[J];Acta Universitis Medicinalis Nahui;2003-04
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