Effects of different inspired oxygen on oxygenation and oxidative stress after one-lung ventilation in lung cancer radical surgery patients
Zi-yu Zhou;Li-ping Li;Yao Liu;Ying-qi Weng;Department of Anesthesiology, Xiangya Hospital, Central South University;Hunan Provincial Maternal and Child Health Care Hospital;
Objective To investigate the effects of different inspired oxygen fraction(Fi O_2) on oxygenation and oxidative stress after one-lung ventilation(OLV) in lung cancer radical surgery patients. Methods Sixty patients of lung cancer scheduled for pulmonary lobectomy were randomly divided into two groups with 30 cases in each group. Different Fi O_2 were given after starting OLV: Fi O_2 in the group A was 100%, Fi O_2 in the group B was 50%. The radial artery and right atrial blood of all the patients were taken to measure oxygenation index(Pa O_2/Fi O_2), respiratory index(RI) and intrapulmonary shunt fraction(Qs/Qt) before starting OLV in the lateral position(T_0), 30 min after one-lung ventilation(T_1), before the end of one-lung ventilation(T_2),after closure of thoracic cavity(T_3) and 2 hours after operation(T_4). The radial artery blood was also used to measure plasma superoxide dismutase(SOD) and malondialdehyde(MDA). Results From T1 to T4, RI of the group B was lower than that of the group A(P 0.05), Qs/Qt of the group B was also lower than that of the group A(P 0.05). At T_4, MDA in the group B was lower than that in the group A, while SOD was higher than that in the group A(P 0.05). Conclusions After starting one-lung ventilation, 50% Fi O_2 can reduce Qs/Qt and oxidative stress, and improve oxygenation function.
【CateGory Index】： R614;R734.2