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《Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases》 2004-05
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Study on Making Rat Models of Nonalcoholic Fatty Liver by Injecting CCl_4 Hypodermically in Smaller Dose and Taking Food Full of Fat

GU Kebo 1, ZHANG Zhuo 2, LI Daoben 3, et al.1.Department of Respiration and Digestion,Beijing Hospital of Integrative Medicine (Beijing,100039)China  
Objective: To analyze the rat models of nonalcoholic fatty liver (NAFL) which were made by a compound method of injecting CCl 4 hypodermically in smaller dose twice a week and taking food full of fat daily at the same time, and to investigate the effects of the method on the alteration of the liver of those rat models. Methods: The smaller dose group of rat NAFL model was made by a compound method of injecting 40% CCl 4 hypodermically twice a week in a 0.2ml/100g dose in the previous 3 weeks and in a 0.1ml/100g dose in the later 3 weeks, and the other group by injecting 40% CCl 4 hypodermically twice a week in a 0.3ml/100g dose, and at the same time taking food full of fat daily for 6 weeks. Then, 6 weeks later, all rats were killed. And liver function, the content of serum TC, TG and HDL-C, and the content of TG and TC in liver tissues were measured. Then those data were analyzed by software SAS 8.1(TS1M0) using F test and q test. Results: The smaller dose group could not only promote the content of TG in liver tissues and the content of serum TG and TC 6 weeks later, but also make less lesion with liver function than that method which were injecting CCl 4 hypodermically in a common dose such as 0.3ml/100g twice a week and taking food full of fat daily. Conclusion: Injecting CCl 4 hypodermically in smaller dose twice a week and taking food full of fat daily at the same time for 6 weeks can not only make satisfied rat models of NAFL but also diminish the lesion of liver function. So we deem that it is a good choose for correlative studies.
【CateGory Index】: R575.5
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