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《Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases》 2011-04
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Experimental study of Gynostemma pentaphyllum on inhibiting lipid deposition in rabbit liver with nonalcohol fatty liver disease

LIU QI-ZHENG,SUN XI-JIE,TAN HUA-BING,et al.Department of Infectious Disease,Renmin Hospital of Hubei College of Medicine(Shiyan Hubei,442000)China  
Objective:To study the effect of gynostemma pentaphyllum inhibiting lipid deposition in rabbit liver with nonalcohol fatty liver disease,and discuss the mechanism.Methods: Forty Japanese adult male white rabbits with NAFLD were randomly divided into intervention group of gynostemma pentaphyllum(Group A),intervention group of simvastatin(Group B),pattern group(Group C),the control group(Group E),respectively every group was given high fat and gynostemma pentaphyllum diet 5g/kg,high fat and simvastatin diet 5g/kg,high fat diet,standard diet,the experimental cycle was 9 weeks.And synchronously tested triglyceride(TG),cholesterol(TCh) before and after experiment.Made liver tissue homogenate,detected the weight of TG in liver tissue homogenate.Pathological changes of liver tissue were observed in order to realize the degree of NNAFLD.Results:①TCh and TG level: Before and after the experiment group A,group B and group C there was a significant difference(P0.01).After the feeding,TG and TCh of group A and group B were lower than group C,there was a significant difference(P0.01);the TG of group A were lower than group B,there was a significant difference(P0.01);the TCh of group B were lower than group A,there was a significant difference(P0.01).②The TG level of liver tissue: The TG of group A and group B were lower than group C,there was a significant difference(P0.01).The TG of group A were lower than group B,there was a significant difference(P0.01).③Liver pathology: The liver of group D was ruddy soft,the livers of group A,B,C were diffuse enlargement,edge blunt and thick,tawny.The colour and lustre of group A was ruddyer than group B and group C;the degree of enlargement was lighter.With the Trypan-blue,structure and cells form of group D was normal,2/3 above cell of group A changed with adipose kind,one hundred percent nearly cell of group B and group C changed with adipose kind.Conclusion:Gynostemma pentaphyllum can reduce the lipid deposition weight in rabbit liver with NAFLD.
【Fund】: 湖北省教育厅科研项目(No.B200624012);; 十堰市科技攻关项目计划(No.2005075D)
【CateGory Index】: R285.5
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