Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《世界胃肠病学杂志(英文版)》 2005-45
Add to Favorite Get Latest Update

Correlation between the expressions of gastrin, somatostatin and cyclin and cyclin-depend kinase in colorectal cancer

Pei Wu, Jia-Ding Mao, Jing-Yi Yan, Jing Rui, You-Cai Zhao, Xian-Hai Li, Guo-Qiang Xu, Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China You-Cai Zhao, Guo-Qiang Xu, Department of Pathology, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China  
AIM: To explore the correlation between the expressions of gastrin (GAS), somatostatin (SS) and cyclin, cyclin-dependent kinase (CDK) in colorectal cancer, and to detect the specific regulatory sites where gastrointestinal hormone regulates cell proliferation. METHODS: Seventy-nine resected large intestine carcinomatous specimens were randomly selected. Immunohistochemical staining for GAS, SS, cyclin D1, cyclin E, cyclin A, cyclin B1, CDK2 and CDK4 was performed according to the standard streptavidin-biotin-peroxidase (S-P) method. According to the semi-quantitative integral evaluation, SS and GAS were divided into high, middle and low groups. Cyclin D1, cyclin E, cyclin A, cyclin B1, CDK2, CDK4 expressions in the three GAS and SS groups were assessed. RESULTS: The positive expression rate of cyclin D1 was significantly higher in high (78.6%, 11/14) and middle GAS groups (73.9%, 17/23) than in low GAS group (45.2%, 19/42) (P0.05, x2high vs low = 4.691; P0.05, x2middle vs low = 4.945). The positive expression rate of cyclin A was significantly higher in high (100%, 14/14) and middle GAS groups (82.6%, 19/23) than in low GAS group (54.8%, 23/42) (P0.01, x2high vs low = 9.586; P0.05,x2middle vs low = 5.040). The positive expression rate of CDK2 was significantly higher in high (92.9%, 13/14) and middle GAS groups (87.0%, 20/23) than in low GAS group (50.0%, 21/42) (P0.01,x2high vs low=8.086; P0.01,x2middle vs low = 8.715). The positive expression rate of CDK4 was significantly higher in high (78.6%, 11/14) and middle GAS groups (78.3%, 18/23) than in low GAS group (42.9%, 18/42) (P0.05, x2high vs low= 5.364; P0.01, x2middle vs low = 7.539). The positive expression rate of cyclin E was prominently higher in low SS group (53.3%, 24/45) than in high (9.1%, 1/11) and middle (21.7%, 5/23) SS groups (P0.05, x2high vs low= 5.325; P0.05, x2middle vs low = 6.212). The positive expression rate of CDK2 was significantly higher in low SS group (77.8%, 35/45) than in high SS group (27.3%, 3/11) (P0.01,x2high vs low = 8.151). There was a significant positive correlation between the integral ratio of GAS to SS and the semi-quantitative integral of cyclin D1, cyclin E, cyclin A, CDK2, CDK4 (P0.05, D1rs = 0.252; P0.01, Ers = 0.387; P0.01, Ars = 0.466; P0.01, K2rs = 0.519; P0.01,K4rs= 0.434). CONCLUSION: The regulation and control of gastrin, SS in colorectal cancer cell growth may be directly related to the abnormal expressions of cyclins Dl, A, E, and CDK2, CDK4. The regulatory site of GAS in the cell cycle of colorectal carcinoma may be at the G1, S and G2 phases. The regulatory site of SS may be at the entrance of S phase.
【Fund】: Supported by the Natural Science Foundation of Anhui Province No.03043704
【CateGory Index】: R735.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 Li Wei;Zhang Geng;Wang Hailun;Wang Liang;The Second Department of General Surgery,Cangzhou Central Hospital;;Expression of Cyclin E,proliferation cell nuclear antigen and matrix metalloproteinase-9 in colorectal carcinoma cells and the significance[J];中华实验外科杂志;2017-01
2 Jia-Ding Mao;Pei Wu;Jian-Xiong Huang;Jian Wu;Guang Yang;Department of General Surgery,the First Affiliated Yijishan Hospital of Wannan Medical College;;Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma[J];World Journal of Gastroenterology;2014-35
3 YAN Jing-yia,CHEN Xiao-leia,SHENG Xiana,ZHANG Sheng-huib,ZHOU Hong-zhonga,HUANG Ying-penga.a.Department of General Surgery;b.Medical Science Institute;The first Affiliated Hospital,Wen Zhou Medical College,Wen Zhou 325000,China;Effects of gastrin receptor antagonist and cyclooxygenase-2 inhibitor on proliferation and the cell cycle of the large intestine carcinoma cell lines LoVo cultured in vitro[J];外科理论与实践;2009-05
【Co-references】
Chinese Journal Full-text Database 8 Hits
1 Wanqing Chen 1 , Rongshou Zheng 1 , Siwei Zhang 1 , Ping Zhao 1 , Guanglin Li 2 , Lingyou Wu 2 , Jie He 1 1 National Office for Cancer Prevention and Control, National Cancer Center, Beijing 100021, China; 2 Bureau of Disease Prevention and Control, Ministry of Health, Beijing 100044, China;Report of incidence and mortality in China cancer registries, 2009[J];Chinese Journal of Cancer Research;2013-01
2 Eduardo Chueca,Angel Lanas,Elena Piazuelo,IIS Aragon,Aragon Institute of Health Sciences,50009 Zaragoza,Spain Angel Lanas,Elena Piazuelo,Networked Biomedical Research Center Hepatic and Digestive Diseases(CIBERehd),C/Corcega 180 bajos dcha,08036 Barcelona,Spain Angel Lanas,Elena Piazuelo,Department of Medicine,Psychiatry and Dermatology,Medical University of Zaragoza,C/Domingo Miral,50009 Zaragoza,Spain Angel Lanas,Service of Gastroenterology,Hospital Clinico Universitario,Avda.San Juan Bosco 15,50009 Zaragoza,Spain;Role of gastrin-peptides in Barrett's and colorectal carcinogenesis[J];World Journal of Gastroenterology;2012-45
3 Huaqiu ZHANG,Qin YAN,Shutian XU,Yibo OU,Fei YE,Baofeng WANG,Ting LEI,Dongsheng GUO # Department of Neurosurgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Association of Expression of Leucine-rich Repeats and Immunoglobulin-like Domains 2 Gene with Invasiveness of Pituitary Adenoma[J];Journal of Huazhong University of Science and Technology(Medical Sciences);2011-04
4 ZHANG Yu,CUI Yao-yuan,WU Wei-zhong,et al.Department of Neurosurgery,Zhongshan Hospital of Fudan University, Shanghai 200032,China;Effect of STAT3 signal pathway on the invasiveness of human glioma cell lines[J];中华实验外科杂志;2008-08
5 Jia-Ding Mao, Pei Wu, Ying-Lin Yang, Jian Wu, He Huang, Department of General Surgery, the First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China;Relationship between expression of gastrin, somatostatin,Fas/FasL and caspases in large intestinal carcinoma[J];World Journal of Gastroenterology;2008-18
6 Pei Wu, Jia-Ding Mao, Jing-Yi Yan, Jing Rui, You-Cai Zhao, Xian-Hai Li, Guo-Qiang Xu, Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China You-Cai Zhao, Guo-Qiang Xu, Department of Pathology, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China;Correlation between the expressions of gastrin, somatostatin and cyclin and cyclin-depend kinase in colorectal cancer[J];World Journal of Gastroenterology;2005-45
7 Jia-Ding Mao, Pei Wu, Xiang-Hou Xia, Ji-Qun Hu, Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China Wen-Bin Huang, Guo-Qiang Xu, Department of Pathology, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China;Correlation between expression of gastrin, somatostatin and cell apoptosis regulation gene bcl-2/bax in large intestine carcinoma[J];World Journal of Gastroenterology;2005-05
8 ZHANG You-cheng, WANG Shan, ZHANG Hui, YE Ying-jiang, LIANG Bin, CUI Zhi-rong. Department of Surgery, Peking University People′s Hospital, Beijing 100044,China;Effects of selective cyclooxygenase-2 inhibitor NS-398 on 5-fluorouracil chemotherapy and progression of colon cells:an experimental study[J];中华医学杂志;2004-07
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 Bian Honglei;Yu Shuoyang;Zhang Shengjun;Gao Xin;Department of Colorectal Surgery,the Third Hospital of Hebei Medical University;Department of Colorectal Surgery,People's Hospital of Yongqing County;ICU of Department of Anesthesiology,the Second Hospital of Hebei Medical University;;Role and mechanism of Annexin A9 in the proliferation of human colon carcinoma cell line SW620[J];中华实验外科杂志;2018-04
2 ZHAO Ji-xian~*, WU Hui-chao,ZHAO Kui.*Department of Digest Internal Medicine,The Second Affiliated Hospital of Heibei North University, Xuanhua 075100,China;Effects of gastrin and proglumide on the expression of EGF and VEGF in colonic cancer cell lines HT-29[J];疑难病杂志;2011-08
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved