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《世界胃肠病学杂志(英文版)》 2009-33
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Problems associated with glucose toxicity:Role of hyperglycemia-induced oxidative stress

Shinji Kawahito, Hiroshi Kitahata, Shuzo Oshita, Department of Anesthesiology, Tokushima University Medical and Dental Hospital, 3-18-15 Kuramoto, Tokushima 770-8503, Japan  
Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic superphysiological glucose concentration negatively affects a large number of organs and tissues. Glucose toxicity means a decrease in insulin secretion and an increase in insulin resistance due to chronic hyperglycemia. It is now generally accepted that glucose toxicity is involved in the worsening of diabetes by affecting the secretion of β-cells. Several mechanisms have been proposed to explain the adverse effects of hyperglycemia. It was found that persistent hyperglycemia caused the functional decline of neutrophils. Infection is thus the main problem resulting from glucose toxicity in the acute phase. In other words, continued hyperglycemia is a life-threatening risk factor, not only in the chronic but also the acute phase, and it becomes a risk factor for infection, particularly in the perioperative period.
【CateGory Index】: R587.1
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Chinese Journal Full-text Database 2 Hits
1 LI Lei*,ZHANG Hai-jun,GUO Li-jun,WANG Xue-ying,GAO Wei*Department of Cardiology,Peking University Third Hospital,Beijing 100083,China;Effects of diabetes mellitus and glycemic control on prognosis of chronic heart failure[J];Clinical Focus;2008-10
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