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Effect and Molecule Psychophysical Mechanism Analysis of Tacrolimus Ointment in Treating Male Patients with Pruritus Ani

XIE Zhiqiang,LAN Yuzhen Peking University Third Hospital,Beijing 100191,China  
Objective To investigate the effect and mechanism of tacrolimus ointment 0.1% in treating adult male patients with pruritus ani.Methods The severity of pruritus(SP) and a basic syntax and molecular substrate(molecular psychophysics) of nociception and pruriception established by temperature-sensitive transient receptor potential(TRP) channels were used to evaluate the severity of pruritus and skin sensory phenomenon.Results The SP score were found to be reduced significantly in 41 patients with pruritus ani after using topical tacrolimus ointment 0.1%.Among them,34(82.9%)patients showed positive capsaicin-like response(i.e.burning with consequent rapid amelioration of pruritus or burning sensation).Seven(17.1%) patients showed negative capsaicin-like response.Conclusion Topical tacrolimus may rapidly inhibits or alleviates itch of patients with pruritus ani.The therapeutic effect of topical tacrolimus is relevant to the mechanism that activate or sensitize transient receptor potential vanilloid receptor 1(TRPV1) and desensitizes TRPV1 in the skin sensory afferents.
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