Effects of rhubarb on cytokine expressions in serum and bronchoalveolar lavage fluid in rats with acute lung injury
LI Chunsheng,HE Xinhua,GUI Peichun.Emergency Department,Affiliated Beijing Chaoyang Hospital,Capital University of Medical Sciences,Beijing 100020,China
Objective: To investigate the effects of rhubarb on the cytokine expressions in serum and bronchoalveolar lavage fluid(BALF) in rats with acute lung injury(ALI).Methods: ALI models of rats were reproduced by injecting lipopolysaccharide(LPS) into the sublingual vein.One hundred and fortyfive male Wistar rats were randomly divided into four groups: LPS group,control group,rhubarb treatment group and dexamethasone treatment group.Tumor necrosis factorα(TNFα),interleukin1β(IL1β) and IL8(levels) in serum and BALF were measured,respectively.Results: TNFα,IL1β and IL8 levels in serum and BALF were higher in LPS group than those in the control group(all P0.05),but they markedly(decreased) in both rhubarb and dexamethasone treatment groups than those in LPS group(P0.05 or(P0.01).) Conclusion: The lung and systemic inflammation is the response of ALI in rats induced by LPS.(Rhubarb) and dexamethasone administration can ameliorate both local(in the lungs) and systemic(in blood)(inflammatory) response and their mechanism may inhibit the activities of TNFα,IL1β and IL8.
【CateGory Index】： R285;