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《Chinese New Drugs Journal》 2003-02
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Comparative studies on hepatic protective and choleretic effect of geniposide and crocetin

PENG Jie,QIAN Zhi-yu,LIU Tong-zheng,RAO Shu-yun,QU Bin( Department of Pharmacology,China Pharmaceutical University,Nanjing 210009, China )  
Objective:To compare the effects of geniposide and crocetin,two main principles from Gardenia jasminiodes Eillis ,on the bile secretion in rats and liver injury in mice.Methods:The bile flow rate of rats was observed after intraduodental administration of geniposide and crocetin.Both drugs were administrated ig to mice with liver injury induced by CCl_4 and acetaminophen (AAP). Effects of both drugs on ALT,AST in serum and MDA,GSH,GSH-Px activity in liver of mice were observed and compared.Liver sections were made for pathological examination.Results:Geniposide at doses of 50 and 100mg·kg -1 could significantly increase the bile secretion while the same doses of crocetin decreased it.Geniposide could decrease serum ALT and AST level in CCl_4 and AAP liver injury mice while crocetin showed no such effects.Both drugs could inhibit the increase of MDA, decrease of GSH and GSH-Px activity in CCl_4 and AAP liver injury models. Histological degenerations of the mouse liver were improved,however,geniposide showed more significant effects than crocetin in the above criteria.Conclusion:Geniposide is the chief effective component in Gardenia jasminoides Eillis for choleretic and hepatic protective effect.
【CateGory Index】: R285.5
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