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《Chinese New Drugs Journal》 2003-12
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HPLC measurement of related substances and citicoline content in citicoline sodium and NaCl injection

ZHENG Zhao-hua,CHEN Yu-ying,DU Ying-xiang (Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China)  
Objective:To establish a method for measurement of related substances and citicoline content in citicoline sodium and NaCl injection. Method:Chromatographic conditions were as follows:a C18 column (200mm×4. 6mm,5μm) ,a mobile phase consisting of 0.01mol·L-1 KH2PO4 solution (pH 4.0) ,and a UV detector at 280nm. Results:The related substanese can be completely separated from citicoline. For citicoline sodium,a linear range of 26 - 157μg·mL-1 ,an average recovery of 102.5% , and a RSD of 0.87% were obtained. Conclusion:Related substances in citicoline sodium and NaCl injection can be accurately and selectively measured by the HPLC method and the content of citicoline in the injection can also be determined by this method.
【Key Words】: citicoline sodium HPLC related substances determination injection
【CateGory Index】: R927.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 ;Determination of substances in citicoline sodium glucose injection by ion-paired HPLC[J];Academic Journal of Second Military Medical University;2005-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Tong-xiang,AN Wei(Institute of Chinese Minority Traditional Medicine,Central University for Nationalities,Beijing 100081,China);Content Determination of Berberine Hydrochloride in Qianlietong Soft Capsules by High Performance Liquid Chromatography[J];Journal of Anhui Traditional Chinese Medical College;2009-04
2 ;Determination of substances in citicoline sodium glucose injection by ion-paired HPLC[J];Academic Journal of Second Military Medical University;2005-04
3 TU Bo~1,WANG Li~2(1.Department of Chemistry,Guiyang Medical College,Guiyang 550004,China;2.Guiyang Maidike Medical Science and Technology Development Institute,Guiyang 550002,China);Determination of Geniposide in Fushenning Capsule by HPLC[J];Journal of Guiyang Medical College;2006-01
4 Feng Binbin,Zhang Jianmei,Zhu Huifeng,et al TCM College of Xinan University,Chongqing(400716);Quality Standard Study on Danqi Tablets[J];Journal of Zhejiang University of Traditional Chinese Medicine;2010-01
5 LI Dao-ming(Xinyang Institute for Food and Drug control of Henan province,Xinyang 464000,China);Study on the bacterial endotoxins test of Shenmai injection[J];Strait Pharmaceutical Journal;2008-03
6 CHENG Zhi,LIU Chunyyan;Effect of Essential Oil on Prevention of Pressure Ulcers[J];Journal of Nursing Science;2009-14
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8 ;Investigation on the Effects of Ultrasonication in Drug Dissolving[J];Guiding Journal of TCM;2007-08
9 HUANG Hai-wei Changsha 3rd People s Hospital,Changsha,China,410007;Determination of Naringin in Weitong Wan by HPLC[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2009-06
10 QU Yan-mei(Pharmaceutical Branch,Northeast Tiger Pharmaceutical Co.,Ltd., Jilin 132013,China);Study on factors influencing the vitality test for lysozyme lozenge[J];Journal of Changchun University of Technology(Natural Science Edition);2006-04
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 XU Ming Quan, ZENG Fan (Guangdong Institute of Materia Medica, Guangzhou 510440);Determination of Ara-AMP by Ion Pair HPLC[J];Chinese Journal of Pharmaceuticals;2001-02
2 GU Song Qing (Shanghai Institute for Drug Control, Shanghai 200233);Determination of Citicoline Sodium and Its Injection by HPLC[J];Chinese Journal of Pharmaceuticals;2002-08
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