Synthesis of ioversol,a non-ionic x-ray contrast agent
LUO Shi-neng,ZOU Pei,LIU Ya-ling,XIE Min-hao,HE Yong-jun, YANG Zheng (Jiangsu Institute of Nuclear Medicine , Wuxi 214063, China )
Objective:To synthesize ioversol,a non-ionic x-ray contrast agent. Methods: loversol was synthesized by choloracetylation, dechlorination, and alkylation of 5-amino-N,N '-bis(2,3-dihy-droxypropyl)-2,4,6-triiodoisophthalamide.The crude product was treated with methanol,732 and 717 resins successionally and purified by recrystallization from butanol. Results: That the structure of the product obtained by the process was confirmed by IR,1H-NMR,13CNMR,MS (FAB) and elemental analysis. Conclusion: A simple and convenient method for synthesis of ioversol is provided and it is suitable for pharmaceutical industry.