Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese New Drugs Journal》 2005-02
Add to Favorite Get Latest Update

Determination of residual solvents in ioversol by head space-gas chromatography

ZOU Pei~1, LUO Shi-neng~1, WANG Lin-xiang~2, LIU Ya-ling~1, XIE Min-hao~1, HE Yong-jun~1(1 Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China; 2 Centre of Analysis, Southern Yangtze University, Wuxi 214036, China)  
Objective: To establish a method for quantification of residual methanol, n-butanol and 2-methoxyethanol in drug substance ioversol. Methods: Samples dissolved in N, N-dimethylacetamide were loaded onto the head space-GC and then was equilibrated at 80℃ for 45min. Toluene was used as internal standard. The optimal gas chromatography was run in a PEG20M capillary column (30m×0.53mm). The initial column temperature was kept at 50℃ for 2min. The column temperature was then escalated to 200℃ at the rate of 5℃·min~(-1) and subsequently sustained for 10min. The temperature at the injection port and the FID detector were 220℃ and 250℃, respectively. N_2 was used as carrier gas at a flow rate of 1mL·min~(-1). Results: Methanol, n-butanol and 2-methoxyethanol showed a linear plot within 61.5~418.9μg·mL~(-1), 59.3~419.5μg·mL~(-1) and 20~140μg·mL~(-1), respectively, with a mean recovery of 97.7%, 99.5% and 98.6%, respectively. Conclusion: The sensitive and accurate method was reliable in the quantification of residual solvents.
【CateGory Index】: R927
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 LUO Shi-neng,ZOU Pei,LIU Ya-ling,XIE Min-hao,HE Yong-jun, YANG Zheng (Jiangsu Institute of Nuclear Medicine , Wuxi 214063, China );Synthesis of ioversol,a non-ionic x-ray contrast agent[J];Chinese New Drugs Journal;2004-04
2 ZOU Pei1,2,LUO Shi-neng1,LIU Ya-ling1,XIE Min-hao1,HE Yong-jun1,SHEN Yong-jia2(1 Jiangsu Institute of Nuclear Medicine,WuXi 214063,China;2 Institute of Fine Chemicals,East China University of Science and Technology,Shanghai 200237,China);HPLC determination of ioversol[J];Chinese Journal of New Drugs;2004-S1
Chinese Journal Full-text Database 10 Hits
1 ZHANG Jing 1 ,SHAN Bao-en 1, ,LIU Gang-san 2 , ZHAO Xue-tao 1 ,CHEN Shu-hong 2 (1.Research Center,the Fourth Hospital of Hebei Medical University,Shijiazhuang050011,Hebei,China;2.New Drug Research and Development Co.,Ltd.of North China Pharmaceutical Corporation,Shijiazhuang050015,Hebei,China);Anti-tumor Activity of Extract from Periploca Sepium Bge[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-02
2 ZHAO Su-qin (Editor Department of Qinghai Nationalities Institute,Xining,Qinghai 810007);Determination of Content of Bergenin in Bergenrae pacumbis by RP-HPLG[J];Journal of Anhui Agricultural Sciences;2006-11
3 PANG Zhen-ling et al (Department of Life Science,Nanyang Normal College,Nanyang,Henan 473061);Study on Microwave-Assisted Extraction of Polysaccharides from Actinidia Chinensis Fruit[J];Journal of Anhui Agricultural Sciences;2006-11
4 WU Song-quan et al(Laboratory of Northeast Forestry University,Haerbin,Heilongjiang 150040);Optimization of RAPD Reaction System for Radix Astragali[J];Journal of Anhui Agricultural Sciences;2006-14
5 MENG Li et al (Henan Institute of Science and Technology,Xinxiang,Henan 453003);Effect of the Maceration Extraction from the Vegetables Umbelliferae Family on Pleurotus ferulae Lanzi Hypha Growth[J];Journal of Anhui Agricultural Sciences;2006-19
6 MENG Li et al (Henan Institute of Science and Technology,Xinxiang,Henan 453003);Effect of Traditional Chinese Medical in Umbelliferae Family on Pleurotus ferulae Lanzi Hypha Growth[J];Journal of Anhui Agricultural Sciences;2006-21
7 ZHANG Ying-cai et al (School of Life Science,Ningxia University,Yinchuan,Ningxia 750021);Summary of Researches on Anthraquinone Compounds of Rheum Tanguticum Maxim.et Bal. Var. Liupanshanense Cheng et Kao[J];Journal of Anhui Agricultural Sciences;2007-01
8 WU Xiao-chun et al(Key Laboratory of Active Ingredients in Natural Medicines of Jiangxi Province,Bio-engineering Institute of Yichun College,Yichun,Jiangxi 336000);Comparison of Total Flavonoid Content between Wild and Planted Ainsliaea fragrans Champ.[J];Journal of Anhui Agricultural Sciences;2007-23
9 XIAO Zhong-feng et al(Shandong Key Laboratory for Yellow River Delta Eco-Environmental,Binzhou University,Binzhou,Shandong 256603);Determination of Trace Elements in Descurainia sophia by FAAS[J];Journal of Anhui Agricultural Sciences;2007-33
10 ZHANG Ai-hua et al (College of Traditional Chinese Medicinal Materials,Jilin Agricultural University,Changchun,Jilin 130118);RAPD Analysis on 2 Species of Northern Medicinal Materials[J];Journal of Anhui Agricultural Sciences;2008-07
China Proceedings of conference Full-text Database 10 Hits
1 Siu-kay WONG 1,Sik-yiu KWAN 1,Shu-ki TSUI 1,Tai-lun TING 1,Xiao-li SU 2,Rui-chao LIN 2,Sau-wan CHENG 3,Kwok-pui FUNG 3 1.Government Laboratory,HKSAR;2.National Institute for the Control of Pharmaceutical and Biological Products;3.The Chinese University of Hong Kong;Study on Quality Control Methods for Realgar[A];[C];2011
2 HAN Jin-le,JIA Ji-zong,LI Chuang,YANG Liang,HE De-lei,LI Juan,YE Xiang-zhong,LI Yimin Beijing Wantai Biological Pharmacy Enterprise Co.,Ltd.Beijing 102206,China National Institute of Diagnostics and Vaccine Development in Infectious Diseases,School of Life Sciences,Xiamen University,Xiamen 361005,China;The Development and Application of a Quantitative ELISA Detection Method for Enterovirus 71 Antigen[A];[C];2011
3 ;The extraction and the chemical component analysis of the volatile oil of manyinflorescenced sweetvetch root from Minxian county,Gansuprovince[A];[C];2011
4 YE Zi-pingl, YUAN Hong-zhong2, ZHAOKaj2 (l.Jiangxi xinyu Chinese Hospital, 2. Hebei Kingscience pharmaceutical Technology Co.,Ltd, Shijiazhuang 050091, China);Determination of mollugin in Biyuan Soft CapsuLe[A];[C];2010
5 Zhang Yufei, Tu Bengsheng,Shao Xiuli (College of Information Technical Science, Nankai University. Tianjin 300071);Modeling of Drip Velocity Soft Sensor in Chinese Materia Medica Pilule Manufacturing Process Based on PCA-FUZZY Hybrid Modeling Method[A];[C];2005
6 Traditional Chinese and Mongolian medical Hospital of Inner Mongolian. China(010020)Wu li ji tege si Bao shuzhe post code;The History and the present development situation of the Preparation of Kusnezoff monkshood in Traditional Mongolian Medicine[A];[C];2005
7 Hasi Bagen Bao Jianhua Xu Hong Lin Yan (ALashan League Institute for Drug Control, Inner Mongolia, 750300 Inner Mongolian Institute for Drug Control, Huhhot, 010020);Assay of Geniposide in Harishierwei Capsules by HPLC[A];[C];2006
8 Lin Qixun , Tong Jin-hua, Fu Ying, Li Jing, Chen Xue Zhen, Chen Li Hua, Huang Jin Zhi (College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002; Experimentation Station for Technology Development on Agricultural Products, Fuzhou 350002; Advanced Food Technology, CT, USA 06033);Study on Loquat Leaves Beverage Based on Stokes Law[A];[C];2006
9 LI Hong-jian, GU Da-jian, SUN Shu-juan, SU Le-qun ,HUANG Xin (Shandong Province Qianfoshan Hospital, Jinan 250014, China);Study on dissolution of tetrahydropalmatine in Yuanhu Zhitong Dispersible Tablets in vitro[A];[C];2005
10 SU Le-qun, GU Wei-ping, ZHANG Man-hong, HUANG Xin ( Qianfoshan Hospital Shandong Province, Jinan, 250012, China; Instituation of Medicine and Industry of Shandong Province, Jinan, 250100, China);Study on Preparation of Yuanhuzhitong Dispersible Tablet[A];[C];2005
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved