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《Chinese New Drugs Journal》 2005-10
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Evaluation of gravimetry in the rat single-pass intestinal perfusion technique

NIE Shu-fang,PAN Wei-san,YANG Xing-gang,LIU Hong-fei,LIU Zhi-dong(Department of Pharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China)  
Objective:To evaluate if the gravimetry improves the efficiency of the rat single-pass intestinal perfusion technique.Methods: Vinpocetine was used as a model drug.The values of net water flux(NWF),drug absorption rate constant(K_a) and drug apparent intestinal permeability(P_(app)) by the gravimetry were compared with the ones by phenol red assay.The values of MWF and P_(app) prior to and post the density correction were analyzed in the gravimetry based on the assumption of a perfusion density of 1.0(g·mL~(-1)).Results: The values of NWF by the gravimetry were significantly larger than the ones by the phenol red assay((P0.05));the K_a and P_(app) by the gravimetry were slightly higher than the ones by the phenol red assay((P0.05).) The gravimetry significantly reduced the systematic errors,and the density correction in the gravimetry provided more reliable results.Conclusion: The gravimetry may significantly correct the perfusion volume in the rat single-pass intestinal perfusion technique,which prevents the results from the systematic errors due to the addition of an external "nonabsorbed" marker.
【CateGory Index】: R96
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